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Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers

Author

Pueyo, N.

Navarro, J. B.

Fatjó-Vilas Mestre, Mar

de la Osa, N.

Penelo Werner, Eva

Fañanás Saura, Lourdes

Ezpeleta, L.

Publication date

2022-03-10T18:33:22Z

2022-03-10T18:33:22Z

2021-10-01

2022-03-10T18:33:23Z

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Abstract

Background and Objectives: From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene (MAOA-uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA-uVNTR results in differential enzyme activity, so that high-activity alleles (MAOA-H) are linked to reduced dopamine, serotonin, and norepinephrine availability in comparison to low-activity allele (MAOA-L). As MAOA-uVNTR has been previously described to moderate the relationship between childhood parental maltreatment and aggressive and antisocial behavior, it may also play a role in CU traits etiology.

Document Type

Article

Published version

Language

English

Subjects and keywords

Amines; Trastorns de la conducta en els infants; Amines; Behavior disorders in children

Publisher

Universidad de Zaragoza

Related items

Reproducció del document publicat a: https://doi.org/10.1016/j.ejpsy.2021.02.003

The European Journal of Psychiatry, 2021, vol. 35, num. 4, p. 225-233

https://doi.org/10.1016/j.ejpsy.2021.02.003

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Rights

cc-by-nc (c) Pueyo, N. et al., 2021

https://creativecommons.org/licenses/by-nc/4.0/

This item appears in the following Collection(s)

Biologia Evolutiva, Ecologia i Ciències Ambientals [1903]

ISGlobal - Institut de Salut Global de Barcelona [60729]