A Novel, Extremely Bioavailable Cocrystal of Pterostilbene

Publication date

2022-02-25T10:57:52Z

2022-03-03T06:10:26Z

2021-03-03

2022-02-25T10:57:52Z

Abstract

New multicomponent solid forms of the nutraceutical pterostilbene have been discovered and characterized through experimental cocrystal screening. Among the coformers tested, picolinic acid formed a cocrystal with a 10-fold enhancement of oral bioavailability in rats, which converts the new cocrystal into a very promising candidate for new formulations of pterostilbene with improved performance.

Document Type

Article


Accepted version

Language

English

Subjects and keywords

Cristal·lografia; Crystallography

Publisher

American Chemical Society

Related items

Versió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.0c01716

Crystal Growth & Design, 2021, vol. 21, num. 4, p. 2315-2323

https://doi.org/10.1021/acs.cgd.0c01716

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Rights

(c) American Chemical Society , 2021