dc.contributor.author
Morales, Paula
dc.contributor.author
Navarro Brugal, Gemma
dc.contributor.author
Gómez-Autet, Marc
dc.contributor.author
Redondo, Laura
dc.contributor.author
Fernández-Ruiz, Javier
dc.contributor.author
Pérez-Benito, Laura
dc.contributor.author
Cordomí, Arnau
dc.contributor.author
Pardo, Leonardo
dc.contributor.author
Franco Fernández, Rafael
dc.contributor.author
Jagerovic, Nadine
dc.date.issued
2021-07-15T05:49:44Z
dc.date.issued
2021-11-09T06:10:21Z
dc.date.issued
2020-11-09
dc.date.issued
2021-07-15T05:49:45Z
dc.identifier
https://hdl.handle.net/2445/179068
dc.description.abstract
Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1002/chem.202003389
dc.relation
Chemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842
dc.relation
https://doi.org/10.1002/chem.202003389
dc.rights
(c) Wiley-VCH, 2020
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject
Receptors cel·lulars
dc.subject
Interacció cel·lular
dc.subject
Cell receptors
dc.subject
Cell interaction
dc.title
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
