SLAM Family Receptors and Autoimmunity

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RECERCAT Home > Universitat de Barcelona > Biomedicina > Llibres / Capítols de llibre (Biomedicina) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/174341

dc.contributor.author	Sintes, Jordi
dc.contributor.author	Bastos, Ricardo
dc.contributor.author	Engel Rocamora, Pablo
dc.date	2021-02-26T13:16:23Z
dc.date	2021-02-26T13:16:23Z
dc.date	2011-10-26
dc.identifier	http://hdl.handle.net/2445/174341
dc.identifier	272132
dc.identifier.uri	http://hdl.handle.net/2445/174341
dc.description	The immune system is responsible for the defense against a wide array of pathogens but without responding to each individual’s (self) antigens. Autoimmune diseases are characterized by a loss of tolerance to self antigens that leads to the appearance of autoreactive lymphocytes. The main factors that contribute to the development of autoimmunity are genetic susceptibility and infection. Disease susceptibility is the result of the combined action of multiple genes. It has been shown that certain gene polymorphisms can influence the establishment of self-tolerance. The human immune system is a complex machinery involving numerous proteins. Cell-surface proteins expressed by leukocytes are of particular relevance due not only to their participation in the network of interactions that regulate the innate and adaptive immune responses, but also to their potential as excellent targets for diagnostic and therapeutic interventions (Diaz-Ramos et al., 2011). These molecules deliver signals that modulate leukocyte development, activation, survival, clonal expansion, and important effector functions. Some of these cell-surface signaling molecules have the capacity to activate lymphocytes and other leukocytes, while others function as downmodulators of immune responses, playing a key role in the establishment of tolerance to self antigens. Thus, it is not surprising that many of the allelic variants associated with autoimmunity identified, to date, correspond to leukocyte cell-surface molecules (Maier & Hafler, 2009). In this review we will discuss recent observations that point to a key role of signaling lymphocyte activation molecule family (SLAMF) receptors in the development of autoimmunity.
dc.format	22 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	IntechOpen
dc.relation	Reprodució del document publicat a: https://doi.org/10.5772/20641
dc.relation	Chapter 3 in: Mavragani, Clio. 2011. Autoimmune Disorders: Pathogenetic Aspects. ISBN: 978-953-51-6537-8. DOI: 10.5772/802. pp: 53-72
dc.relation	https://doi.org/10.5772/20641
dc.rights	cc by (c) Sintes, Jordi et al., 2011
dc.rights	http://creativecommons.org/licenses/by/3.0/es/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Malalties autoimmunitàries
dc.subject	Autoimmune disease
dc.title	SLAM Family Receptors and Autoimmunity
dc.type	info:eu-repo/semantics/bookPart
dc.type	info:eu-repo/semantics/publishedVersion

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