Universitat de Barcelona
2020-03-11T17:22:44Z
2020-03-11T17:22:44Z
2011-08-18
2020-03-11T17:22:44Z
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
Article
Published version
English
Alcaloides; Acetilcolinesterasa; Malaltia d'Alzheimer; Amaril·lidàcies; Alkaloids; Acetylcholinesterase; Alzheimer's disease; Amaryllidaceae
MDPI
Reproducció del document publicat a: https://doi.org/10.3390/molecules16087097
Molecules, 2011, vol. 16, num. 8, p. 7097-7104
https://doi.org/10.3390/molecules16087097
cc-by (c) Andrade, Jean Paulo de et al., 2011
http://creativecommons.org/licenses/by/3.0/es
