Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Morris, Gerwyn
dc.contributor.author	Vissoci Reiche, Edna Maria
dc.contributor.author	Murru, Andrea
dc.contributor.author	Carvalho, André F.
dc.contributor.author	Maes, Michael
dc.contributor.author	Berk, Michael
dc.contributor.author	Puri, Basant K.
dc.date	2020-01-16T12:59:53Z
dc.date	2020-01-16T12:59:53Z
dc.date	2018-01-02
dc.date	2020-01-14T14:04:43Z
dc.identifier	1559-1182
dc.identifier	http://hdl.handle.net/2445/148019
dc.identifier	3167538
dc.identifier.uri	http://hdl.handle.net/2445/148019
dc.description	Patients with a diagnosis of multiple sclerosis (MS) or major depressive disorder (MDD) share a wide array of biological abnormalities which are increasingly considered to play a contributory role in the pathogenesis and pathophysiology of both illnesses. Shared abnormalities include peripheral inflammation, neuroinflammation, chronic oxidative and nitrosative stress, mitochondrial dysfunction, gut dysbiosis, increased intestinal barrier permeability with bacterial translocation into the systemic circulation, neuroendocrine abnormalities and microglial pathology. Patients with MS and MDD also display a wide range of neuroimaging abnormalities and patients with MS who display symptoms of depression present with different neuroimaging profiles compared with MS patients who are depression-free. The precise details of such pathology are markedly different however. The recruitment of activated encephalitogenic Th17 T cells and subsequent bidirectional interaction leading to classically activated microglia is now considered to lie at the core of MS-specific pathology. The presence of activated microglia is common to both illnesses although the pattern of such action throughout the brain appears to be different. Upregulation of miRNAs also appears to be involved in microglial neurotoxicity and indeed T cell pathology in MS but does not appear to play a major role in MDD. It is suggested that the antidepressant lofepramine, and in particular its active metabolite desipramine, may be beneficial not only for depressive symptomatology but also for the neurological symptoms of MS. One clinical trial has been carried out thus far with, in particular, promising MRI findings.
dc.format	25 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	Springer US
dc.relation	Reproducció del document publicat a: https://doi.org/10.1007/s12035-017-0843-5
dc.relation	Molecular Neurobiology, 2018, vol. 55, num. 8, p. 6282-6306
dc.relation	https://doi.org/10.1007/s12035-017-0843-5
dc.rights	cc by (c) Morris et al., 2018
dc.rights	http://creativecommons.org/licenses/by/3.0/es/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Depressió psíquica
dc.subject	Esclerosi múltiple
dc.subject	Estrès oxidatiu
dc.subject	Mental depression
dc.subject	Multiple sclerosis
dc.subject	Oxidative stress
dc.title	Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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