dc.contributor.author
Ràfols Llach, Clara
dc.contributor.author
Fael, Hanan
dc.contributor.author
Fuguet i Jordà, Elisabet
dc.contributor.author
Outhwaite, Breeze
dc.contributor.author
Lee, Samuel
dc.contributor.author
Ruiz, Rebeca
dc.date.issued
2019-10-29T13:02:08Z
dc.date.issued
2019-10-29T13:02:08Z
dc.date.issued
2018-03-25
dc.date.issued
2019-10-29T13:02:08Z
dc.identifier
https://hdl.handle.net/2445/143444
dc.description.abstract
The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
IAPC Publishing
dc.relation
Reproducció del document publicat a: https://doi.org/10.5599/admet.6.1.497
dc.relation
ADMET & DMPK, 2018, vol. 6 , num. 1, p. 61-70
dc.relation
https://doi.org/10.5599/admet.6.1.497
dc.rights
cc-by (c) Ràfols Llach, Clara et al., 2018
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Enginyeria Química i Química Analítica)
dc.title
Dissolution rates of ciprofloxacin and its cocrystal with resorcinol
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
