Gray/White matter contrast in Parkinson's disease

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Uribe Codesal, Carme
dc.contributor.author	Segura i Fàbregas, Bàrbara
dc.contributor.author	Baggio, Hugo César
dc.contributor.author	Abós, Alexandra
dc.contributor.author	García Díaz, Anna I.
dc.contributor.author	Campabadal, Anna
dc.contributor.author	Martí Domènech, Ma. Josep
dc.contributor.author	Valldeoriola Serra, Francesc
dc.contributor.author	Compta, Yaroslau
dc.contributor.author	Bargalló Alabart, Núria
dc.contributor.author	Junqué i Plaja, Carme, 1955-
dc.date	2019-09-12T12:56:02Z
dc.date	2019-09-12T12:56:02Z
dc.date	2018-03-27
dc.date	2019-09-12T10:25:37Z
dc.identifier	1663-4365
dc.identifier	679931
dc.identifier	29636679
dc.identifier.uri	http://hdl.handle.net/2445/139802
dc.description	Gray/white matter contrast (GWC) decreases with aging and has been found to be a useful MRI biomarker in Alzheimer's disease (AD), but its utility in Parkinson's disease (PD) patients has not been investigated. The aims of the study were to test whether GWC is sensitive to aging changes in PD patients, if PD patients differ from healthy controls (HCs) in GWC, and whether the use of GWC data would improve the sensitivity of cortical thickness analyses to differentiate PD patients from controls. Using T1-weighted structural images, we obtained individual cortical thickness and GWC values from a sample of 90 PD patients and 27 controls. Images were processed with the automated FreeSurfer stream. GWC was computed by dividing the white matter (WM) by the gray matter (GM) values and projecting the ratios onto a common surface. The sample characteristics were: 52 patients and 14 controls were males; mean age of 64.4 ± 10.6 years in PD and 64.7 ± 8.6 years in controls; 8.0 ± 5.6 years of disease evolution; 15.6 ± 9.8 UPDRS; and a range of 1.5-3 in Hoehn and Yahr (H&Y) stage. In both PD and controls we observed significant correlations between GWC and age involving almost the entire cortex. When applying a stringent cluster-forming threshold of p < 0.0001, the correlation between GWC and age also involved the entire cortex in the PD group; in the control group, the correlation was found in the parahippocampal gyrus and widespread frontal and parietal areas. The GWC of PD patients did not differ from controls', whereas cortical thickness analyses showed thinning in temporal and parietal cortices in the PD group. Cortical thinning remained unchanged after adjusting for GWC. GWC is a very sensitive measure for detecting aging effects, but did not provide additional information over other parameters of atrophy in PD.
dc.format	8 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	Frontiers Media
dc.relation	Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00089
dc.relation	Frontiers in Aging Neuroscience, 2018, vol. 10, p. 89
dc.relation	https://doi.org/10.3389/fnagi.2018.00089
dc.rights	cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Malaltia de Parkinson
dc.subject	Envelliment
dc.subject	Ressonància magnètica
dc.subject	Parkinson's disease
dc.subject	Aging
dc.subject	Magnetic resonance
dc.title	Gray/White matter contrast in Parkinson's disease
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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