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Título:	Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea
Autor/a:	Vilaseca, Antoni; Campillo, Noelia; Torres, Marta; Musquera i Felip, Mireia; Gozal, David; Montserrat Canal, José Ma.; Alcaraz Asensio, Antonio; Touijer, Karim A.; Farre, Ramon; Almendros López, Isaac
Notas:	We investigate the effects of intermittent hypoxia (IH), a characteristic feature of obstructive sleep apnea (OSA), on renal cancer progression in an animal and cell model. An in vivo mouse model (Balb/c, n = 50) of kidney cancer was used to assess the effect of IH on tumor growth, metastatic capacity, angiogenesis and tumor immune response. An in vitro model tested the effect of IH on RENCA cells, macrophages and endothelial cells. Tumor growth, metastatic capacity, circulating vascular endothelial growth factor (VEGF) and content of endothelial cells, tumor associated macrophages and their phenotype were assessed in the tumor. In vitro, VEGF cell expression was quantified.Although IH did not boost tumor growth, it significantly increased endothelial cells (p = 0.001) and circulating VEGF (p<0.001) in the in vivo model. Macrophages exposed to IH in vitro increased VEGF expression, whereas RENCA cells and endothelial cells did not. These findings are in keeping with previous clinical data suggesting that OSA has no effect on kidney cancer size and that the association observed between OSA and higher Fuhrman grade of renal cell carcinoma may be mediated though a proangiogenic process, with a key role of macrophages.
Materia(s):	-Síndromes d'apnea del son -Càncer de ronyó -Models animals en la investigació -Sleep apnea syndromes -Renal cancer -Animal models in research
Derechos:	cc-by (c) Vilaseca, Antoni et al., 2017 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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