dc.contributor.author
Benabou Zdaou, Sanae
dc.contributor.author
Garavís, Miguel
dc.contributor.author
Lyonnais, Sébastien
dc.contributor.author
Eritja i Casadellà, Ramon
dc.contributor.author
González, Carlos
dc.contributor.author
Gargallo Gómez, Raimundo
dc.date.issued
2019-02-05T13:25:32Z
dc.date.issued
2019-02-05T13:25:32Z
dc.date.issued
2016-02-09
dc.date.issued
2019-02-05T13:25:32Z
dc.identifier
https://hdl.handle.net/2445/127915
dc.description.abstract
The nature and length of loops connecting cytosine tracts in i-motif structures may affect their stability. In this work, the influence of the nature of the nucleobases located in two of the loops of an intramolecular i-motif is studied using spectroscopy, separation techniques, and multivariate data analysis. Insertion of bases other than thymine induces an additional acid-base equilibrium with pKa~4.5. The presence of two guanine bases in the loops, placed opposite to each other, decreases the thermal stability of the structure. In contrast, thymine and cytosine bases in these positions stabilize the structure
dc.format
application/pdf
dc.publisher
Royal Society of Chemistry
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1039/C5CP07428B
dc.relation
Physical Chemistry Chemical Physics, 2016, vol. 18, num. 11, p. 7997-8004
dc.relation
https://doi.org/10.1039/C5CP07428B
dc.rights
(c) Benabou Zdaou, Sanae et al., 2016
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject
Espectroscòpia de ressonància magnètica nuclear
dc.subject
Cromatografia de permeació per gel
dc.subject
Nuclear magnetic resonance spectroscopy
dc.subject
Gel permeation chromatography
dc.subject
Electrophoresis
dc.title
Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
