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dc.contributor.author | García Layana, Alfredo |
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dc.contributor.author | Ciufo, Gianfranco |
dc.contributor.author | Toledo Atucha, Estefanía |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- |
dc.contributor.author | Corella Piquer, Dolores |
dc.contributor.author | Fitó Colomer, Montserrat |
dc.contributor.author | Estruch Riba, Ramon |
dc.contributor.author | Gómez Gracia, Enrique |
dc.contributor.author | Fiol Sala, Miguel |
dc.contributor.author | Lapetra, José |
dc.contributor.author | Serra Majem, Lluís |
dc.contributor.author | Pintó Sala, Xavier |
dc.contributor.author | Portillo, María P. |
dc.contributor.author | Sorlí, José V. |
dc.contributor.author | Bulló, Mònica |
dc.contributor.author | Vinyoles, Ernest |
dc.contributor.author | Sala Vila, Aleix |
dc.contributor.author | Ros Rahola, Emilio |
dc.contributor.author | Salas Salvadó, Jordi |
dc.contributor.author | Arós, Fernando |
dc.date | 2019-01-02T15:41:22Z |
dc.date | 2019-01-02T15:41:22Z |
dc.date | 2017-05-03 |
dc.date | 2019-01-02T15:41:22Z |
dc.identifier | 2072-6643 |
dc.identifier | 677056 |
dc.identifier | 28467363 |
dc.identifier.uri | http://hdl.handle.net/2445/127103 |
dc.description | Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55-80 years) from the Prevencion con Dieta Mediterronea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. Conclusions: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. |
dc.format | 12 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | MDPI |
dc.relation | Reproducció del document publicat a: https://doi.org/10.3390/nu9050453 |
dc.relation | Nutrients, 2017, vol. 9, num. 5 |
dc.relation | https://doi.org/10.3390/nu9050453 |
dc.rights | cc-by (c) García Layana, Alfredo et al., 2017 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Cuina mediterrània |
dc.subject | Cirurgia de cataractes |
dc.subject | Antioxidants |
dc.subject | Cataractes |
dc.subject | Mediterranean cooking |
dc.subject | Cataract surgery |
dc.subject | Antioxidants |
dc.subject | Cataract |
dc.title | The effect of a mediterranean diet on the incidence of cataract surgery |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |