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| dc.contributor.author | Antelo, Marina |
|---|---|
| dc.contributor.author | Balaguer Prunés, Francesc |
| dc.contributor.author | Shia, Jinru |
| dc.contributor.author | Shen, Yan |
| dc.contributor.author | Hur, Keun |
| dc.contributor.author | Moreira, Leticia |
| dc.contributor.author | Cuatrecasas Freixas, Miriam |
| dc.contributor.author | Bujanda, Luis |
| dc.contributor.author | Giraldez, Maria Dolores |
| dc.contributor.author | Takahashi, Masanobu |
| dc.contributor.author | Cabanne, Ana |
| dc.contributor.author | Barugel, Mario Edmundo |
| dc.contributor.author | Arnold, Mildred |
| dc.contributor.author | Roca, Enrique Luis |
| dc.contributor.author | Andreu, Montserrat |
| dc.contributor.author | Castellví Bel, Sergi |
| dc.contributor.author | Llor, Xavier |
| dc.contributor.author | Jover, Rodrigo |
| dc.contributor.author | Castells Garangou, Antoni |
| dc.contributor.author | Boland, C. Richard |
| dc.contributor.author | Goel, Ajay |
| dc.date | 2018-09-26T10:30:03Z |
| dc.date | 2018-09-26T10:30:03Z |
| dc.date | 2012-09-25 |
| dc.date | 2018-09-26T10:30:03Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 635325 |
| dc.identifier | 23049789 |
| dc.identifier.uri | http://hdl.handle.net/2445/124828 |
| dc.description | Objective Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized as independent factors for increased cancer-related mortality. The methylation status of LINE-1 elements in early-onset CRC has not been analyzed previously. Design We analyzed 343 CRC tissues and 32 normal colonic mucosa samples, including 2 independent cohorts of CRC diagnosed ≤50 years old (n = 188), a group of sporadic CRC >50 years (MSS n = 89; MSI n = 46), and a group of Lynch syndrome CRCs (n = 20). Tumor mismatch repair protein expression, microsatellite instability status, LINE-1 and MLH1 methylation, somatic BRAF V600E mutation, and germline MUTYH mutations were evaluated. Results Mean LINE-1 methylation levels (±SD) in the five study groups were early-onset CRC, 56.6% (8.6); sporadic MSI, 67.1% (5.5); sporadic MSS, 65.1% (6.3); Lynch syndrome, 66.3% (4.5) and normal mucosa, 76.5% (1.5). Early-onset CRC had significantly lower LINE-1 methylation than any other group (p<0.0001). Compared to patients with <65% LINE-1 methylation in tumors, those with ≥65% LINE-1 methylation had significantly better overall survival (p = 0.026, log rank test). Conclusions LINE-1 hypomethylation constitutes a potentially important feature of early-onset CRC, and suggests a distinct molecular subtype. Further studies are needed to assess the potential of LINE-1 methylation status as a prognostic biomarker for young people with CRC. |
| dc.format | 12 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0045357 |
| dc.relation | PLoS One, 2012, vol. 7, num. 9, p. e45357 |
| dc.relation | https://doi.org/10.1371/journal.pone.0045357 |
| dc.rights | cc-by (c) Antelo, Marina et al., 2012 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Càncer colorectal |
| dc.subject | Càncer |
| dc.subject | Epidemiologia genètica |
| dc.subject | Colorectal cancer |
| dc.subject | Cancer |
| dc.subject | Genetic epidemiology |
| dc.title | A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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