Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/124802
| dc.contributor.author | Vidal, Francesc |
|---|---|
| dc.contributor.author | López Dupla, Miguel |
| dc.contributor.author | Laguno Centeno, Montserrat |
| dc.contributor.author | Veloso, Sergio |
| dc.contributor.author | Mallolas Masferrer, Josep |
| dc.contributor.author | Murillas Angoiti, Javier |
| dc.contributor.author | Cifuentes, Carmen |
| dc.contributor.author | Gallart, Lluis |
| dc.contributor.author | Auguet, Teresa |
| dc.contributor.author | Sampériz, Gloria |
| dc.contributor.author | Payeras, Antoni |
| dc.contributor.author | Hernandez, Pilar |
| dc.contributor.author | Arnedo Valero, Mireia |
| dc.contributor.author | Gatell, José M. |
| dc.contributor.author | Richart, Cristóbal |
| dc.date | 2018-09-25T15:10:50Z |
| dc.date | 2018-09-25T15:10:50Z |
| dc.date | 2012-11-02 |
| dc.date | 2018-09-25T15:10:50Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 635486 |
| dc.identifier | 23133602 |
| dc.identifier.uri | http://hdl.handle.net/2445/124802 |
| dc.description | Background and Aims This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα) 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients. Methods The study groups were made of 99 patients (efficacy pharmacogenetic substudy) and of 114 patients (safety pharmacogenetic substudy). Polymorphisms in the following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 and ITPA were assessed. Genotyping was carried out using Sequenom iPLEX-Gold, a single-base extension polymerase chain reaction. Efficacy end-points assessed were: rapid, early and sustained virological response (RVR, EVR and SVR, respectively). Safety end-points assessed were: anemia, neutropenia, thrombocytopenia, flu-like syndrome, gastrointestinal disturbances and depression. Chi square test, Student's T test, Mann-Whitney U test and logistic regression were used for statistic analyses. Results As efficacy is concerned, IL28B and CTLA4 gene polymorphisms were associated with RVR (p<0.05 for both comparisons). Nevertheless, only polymorphism in the IL28B gene was associated with SVR (p = 0.004). In the multivariate analysis, the only gene independently associated with SVR was IL28B (OR 2.61, 95%CI 1.2-5.6, p = 0.01). With respect to safety, there were no significant associations between flu-like syndrome or depression and the genetic variants studied. Gastrointestinal disturbances were associated with ITPA gene polymorphism (p = 0.04). Anemia was associated with OAS1 and CTLA4 gene polymorphisms (p = 0.049 and p = 0.045, respectively), neutropenia and thromobocytopenia were associated with SOCS3 gene polymorphism (p = 0.02 and p = 0.002, respectively). In the multivariate analysis, the associations of the SOCS3 gene polymorphism with neutropenia (OR 0.26, 95%CI 0.09-0.75, p = 0.01) and thrombocytopenia (OR 0.07, 95%CI 0.008-0.57, p = 0.01) remained significant. Conclusions In HCV-HIV coinfected patients treated with PegIFNα and ribavirin, SVR is associated with IL28B rs8099917 polymorphism. HCV treatment-induced neutropenia and thrombocytopenia are associated with SOCS3 rs4969170 polymorphism. |
| dc.format | 9 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0047725 |
| dc.relation | PLoS One, 2012, vol. 7, num. 11, p. e47725 |
| dc.relation | https://doi.org/10.1371/journal.pone.0047725 |
| dc.rights | cc-by (c) Vidal, Francesc et al., 2012 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | VIH (Virus) |
| dc.subject | Genètica humana |
| dc.subject | Farmacogenètica |
| dc.subject | HIV (Viruses) |
| dc.subject | Human genetics |
| dc.subject | Pharmacogenetics |
| dc.title | Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants. |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
Documentos relacionados
Otros documentos del mismo autor/a
Vidal, Francesc; López-Dupla, Miguel; Laguno Centeno, Montserrat; Veloso, Sergi; Mallolas Masferrer, Josep; Murillas, Javier; Cifuentes, Carmen; Gallart, Lluis; Auguet, Teresa; Sampériz, Gloria; Payeras, Antoni; Hernandez, Pilar; Arnedo Valero, Mireia; Gatell, José M.; Richart, Cristóbal
López-Dupla, Miguel; Maymó-Masip, Elsa; Martínez Chamorro, Esteban José; Domingo, Pere (Domingo Pedrol); Leal, Manuel; Peraire, Joaquim; Viladés, Consuelo; Veloso, Sergio; Arnedo, Mireia; Ferrando-Martínez, Sara; Beltrán-Debón, Raúl; Alba, Verónica; Gatell, José M.; Vendrell, Joan; Vidal, Francesc; Chacón, Matilde R.
León, Agathe; Cáceres, César; Fernández, Emma; Chausa, Paloma; Martin, Maite; Codina, Carles; Rousaud, Araceli; Blanch, Jordi; Mallolas Masferrer, Josep; Martínez Chamorro, Esteban José; Blanco, José L.; Laguno Centeno, Montserrat; Larrousse Morellón, Maria; Milinkovic, Ana; Zamora, Laura; Canal, Neus; Miró Meda, José M.; Gatell, José M.; Gómez, Enrique J.; García, Felipe
Berenguer, Juan; Jarrín, Inmaculada; Pérez-Latorre, Leire; Hontañón, Víctor; Vivancos, María J.; Navarro, Jordi; Téllez, María J.; Guardiola Tey, Josep Maria; Iribarren, José A.; Rivero-Juárez, Antonio; Márquez, Manuel; Artero, Arturo; Morano, Luis; Santos, Ignacio; Moreno, Javier; Fariñas, María C.; Galindo, María J.; Hernando, María A.; Montero, Marta; Cifuentes, Carmen; Domingo, Pere; Sanz, José; Domíngez, Lourdes; Ferrero, Oscar L.; De la Fuente, Belén; Rodríguez, Carmen; Reus, Sergio; Hernández-Quero, José; Gaspar, Gabriel; Pérez-Martínez, Laura; García, Coral; Force, Lluis; Veloso, Sergio; Losa, Juan E.; Vilaró, Josep; Bernal, Enrique; Arponen, Sari; Ortí, Amat J.; Chocarro, Ángel; Teira, Ramón; Alonso, Gerardo; Silvariño, Rafael; Vegas, Ana; Geijo, Paloma; Bisbe, Josep; Esteban, Herminia; González-García, Juan; GeSIDA 8514 Study Group
Londoño Hurtado, María Carlota; Riveiro Barciela, Mar; Ahumada, Adriana; Muñoz Gómez, Raquel; Roget, Mercé; Devesa Medina, María J.; Serra, Miguel Ángel; Navascués, Carmen A.; Baliellas Comellas, Mª Carme; Aldamiz Echevarría, Teresa; Gutiérrez, María L.; Polo Lorduy, Benjamín; Carmona, Isabel; Benlloch, Salvador; Bonet, Lucía; García Samaniego, Javier; Jiménez Pérez, Miguel; Morán Sánchez, Senador; Castro, Ángeles; Delgado, Manuel; Gea Rodríguez, Francisco; Martín Granizo, Ignacio; Montes, María Luisa; Morano, Luís; Castaño, Manuel A.; Santos, Ignacio de los; Laguno Centeno, Montserrat; Losa, Juan Emilio; Montero-Alonso, Marta; Rivero, Antonio; Álvaro, Cristina de; Manzanares, Amanda; Mallolas Masferrer, Josep; Barril, Guillermina; González Parra, Emilio; García Buey, Luisa