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| dc.contributor.author | Massanella, Marta |
|---|---|
| dc.contributor.author | Ouchi, Dan |
| dc.contributor.author | Marfil, Silvia |
| dc.contributor.author | Llibre, Josep María |
| dc.contributor.author | Puertas, Maria C. |
| dc.contributor.author | Buzón, María J. |
| dc.contributor.author | Richman, Douglas D. |
| dc.contributor.author | Orna, Elisa |
| dc.contributor.author | Stevenson, Mario |
| dc.contributor.author | Gatell, José M. |
| dc.contributor.author | Domingo, Pere (Domingo Pedrol) |
| dc.contributor.author | Negredo, Eugenia |
| dc.contributor.author | Martínez Picado, Francisco Javier |
| dc.contributor.author | Clotet i Sala, Bonaventura |
| dc.contributor.author | Blanco, Julià |
| dc.date | 2018-03-15T18:35:59Z |
| dc.date | 2018-03-15T18:35:59Z |
| dc.date | 2014-12-02 |
| dc.date | 2018-03-15T18:35:59Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 649155 |
| dc.identifier | 25462535 |
| dc.identifier.uri | http://hdl.handle.net/2445/120809 |
| dc.description | BACKGROUND: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. METHODS: Longitudinal plasma samples (0-48 weeks) from the IntegRal (n = 67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts<350 cells/µl, 14 control and 30 intensified) were assayed for 25 markers. Mann-Whitney, Wilcoxon, Spearman test and linear mixed models were used for analysis. RESULTS: At baseline, different inflammatory markers were strongly associated with HCV co-infection, lower CD4 counts and with cART regimens (being higher in PI-treated individuals), but poorly correlated with detection of markers of residual viral replication. Although raltegravir intensification reduced inflammation in individuals with lower CD4 T-cell counts, no effect of intensification was observed on plasma markers of inflammation in a global analysis. An association was found, however, between reductions in immune activation and plasma levels of the coagulation marker D-dimer, which exclusively decreased in intensified patients on protease inhibitor (PI)-based cART regimens (P = 0.040). CONCLUSIONS: The inflammatory profile in treated HIV-infected individuals showed a complex association with HCV co-infection, the levels of CD4 T cells and the cART regimen. Raltegravir intensification specifically reduced D-dimer levels in PI-treated patients, highlighting the link between cART composition and residual viral replication; however, raltegravir had little effect on other inflammatory markers. |
| dc.format | 15 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0114142 |
| dc.relation | PLoS One, 2014, vol. 9, num. 12, p. e114142 |
| dc.relation | https://doi.org/10.1371/journal.pone.0114142 |
| dc.rights | cc-by (c) Massanella, Marta et al., 2014 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Marcadors bioquímics |
| dc.subject | Infeccions per VIH |
| dc.subject | Inflamació |
| dc.subject | Antiretrovirals |
| dc.subject | Biochemical markers |
| dc.subject | HIV infections |
| dc.subject | Inflammation |
| dc.subject | Antiretroviral agents |
| dc.title | Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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