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dc.contributor.author | Fenutría, Rafael |
---|---|
dc.contributor.author | Martinez, Vanesa Gabriela |
dc.contributor.author | Simões, Inês |
dc.contributor.author | Postigo, Jorge |
dc.contributor.author | Gil, Victor |
dc.contributor.author | Martínez-Florensa, Mario |
dc.contributor.author | Sintes, Jordi |
dc.contributor.author | Naves, Rodrigo |
dc.contributor.author | Cashman, Kevin S. |
dc.contributor.author | Alberola-Ila, José |
dc.contributor.author | Ramos Casals, Manuel |
dc.contributor.author | Soldevila, Gloria |
dc.contributor.author | Raman, Chander |
dc.contributor.author | Merino, Jesús |
dc.contributor.author | Merino, Ramón |
dc.contributor.author | Engel Rocamora, Pablo |
dc.contributor.author | Lozano Soto, Francisco |
dc.date | 2017-07-03T11:23:15Z |
dc.date | 2017-07-03T11:23:15Z |
dc.date | 2014-01-15 |
dc.date | 2017-07-03T11:23:15Z |
dc.identifier | 1932-6203 |
dc.identifier | 647387 |
dc.identifier | 24454761 |
dc.identifier.uri | http://hdl.handle.net/2445/113245 |
dc.description | CD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a negative regulator of antigen-specific receptor-mediated signaling in these cells, and that this would likely be achieved through interaction with CD5 ligand/s (CD5L) of still undefined nature expressed on immune or accessory cells. To determine the functional consequence of loss of CD5/CD5L interaction in vivo, a new transgenic mouse line was generated (shCD5EμTg), expressing a circulating soluble form of human CD5 (shCD5) as a decoy to impair membrane-bound CD5 function. These shCD5EμTg mice showed an enhanced response to autologous antigens, as deduced from the presentation of more severe forms of experimentally inducible autoimmune disease (collagen-induced arthritis, CIA; and experimental autoimmune encephalitis, EAE), as well as an increased anti-tumoral response in non-orthotopic cancer models (B16 melanoma). This enhancement of the immune response was in agreement with the finding of significantly reduced proportions of spleen and lymph node Treg cells (CD4+CD25+FoxP3+), and of peritoneal IL-10-producing and CD5+ B cells, as well as an increased proportion of spleen NKT cells in shCD5EμTg mice. Similar changes in lymphocyte subpopulations were observed in wild-type mice following repeated administration of exogenous recombinant shCD5 protein. These data reveal the relevant role played by CD5/CD5L interactions on the homeostasis of some functionally relevant lymphocyte subpopulations and the modulation of immune responses to autologous antigens. |
dc.format | 15 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0084895 |
dc.relation | PLoS One, 2014, vol. 9, num. 1, p. e84895 |
dc.relation | https://doi.org/10.1371/journal.pone.0084895 |
dc.rights | cc-by (c) Fenutría, Rafael et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Cèl·lules B |
dc.subject | Cèl·lules T |
dc.subject | Limfòcits |
dc.subject | Antígens |
dc.subject | Melsa |
dc.subject | Resposta immunitària |
dc.subject | B cells |
dc.subject | T cells |
dc.subject | Lymphocytes |
dc.subject | Antigens |
dc.subject | Spleen |
dc.subject | Immune response |
dc.title | Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |