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dc.contributor.author | García-Albéniz, Xavier |
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dc.contributor.author | Gallego, Rosa |
dc.contributor.author | Hofhteinz, Ralf Dieter |
dc.contributor.author | Fernández Esparrach, Glòria |
dc.contributor.author | Ayuso Colella, Juan Ramón |
dc.contributor.author | Bombí, Josep Antoni |
dc.contributor.author | Conill, Carles |
dc.contributor.author | Cuatrecasas Freixas, Miriam |
dc.contributor.author | Delgado Rivilla, Salvadora |
dc.contributor.author | Ginès i Gibert, M. Àngels |
dc.contributor.author | Miquel Morera, Rosa |
dc.contributor.author | Pagès Llinàs, M. (Mario) |
dc.contributor.author | Pineda, Estela |
dc.contributor.author | Pereira, María Verónica |
dc.contributor.author | Sosa, Aarón |
dc.contributor.author | Reig, Oscar |
dc.contributor.author | Victoria, Iván |
dc.contributor.author | Feliz, Luis |
dc.contributor.author | Lacy Fortuny, Antonio Ma. de |
dc.contributor.author | Castells Garangou, Antoni |
dc.contributor.author | Burkholder, Iris |
dc.contributor.author | Hochhaus, Andreas |
dc.contributor.author | Maurel Santasusana, Joan |
dc.date | 2017-05-25T07:54:10Z |
dc.date | 2017-05-25T07:54:10Z |
dc.date | 2014-11-14 |
dc.date | 2017-05-25T07:54:11Z |
dc.identifier | 1007-9327 |
dc.identifier | 645148 |
dc.identifier | 25400468 |
dc.identifier.uri | http://hdl.handle.net/2445/111525 |
dc.description | AIM: To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy. METHODS: Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy. Laparoscopic surgery was planned after 5-8 wk. Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol. Patients with ypT1-2N0 or ypT3-4 or N+ were offered 5-fluorouracil-based adjuvant treatment on an individual basis. An external cohort was used as a reference for the findings. RESULTS: One hundred and seventy six patients were treated with induction chemoradiotherapy and 170 underwent total mesorectal excision. Cancer staging of ypT0N0 was achieved in 26/170 (15.3%) patients. After a median follow-up of 58.3 mo, patients with ypT0N0 had five-year disease-free and overall survival rates of 96% (95%CI: 77-99) and 100%, respectively. We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation. The inherent good prognosis of these patients will have implications for clinical trial design and care of patients. CONCLUSION: Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. |
dc.format | 11 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Baishideng Publishing Group |
dc.relation | Reproducció del document publicat a: https://doi.org/10.3748/wjg.v20.i42.15820 |
dc.relation | World Journal of Gastroenterology, 2014, vol. 20, num. 42, p. 15820-15829 |
dc.relation | https://doi.org/10.3748/wjg.v20.i42.15820 |
dc.rights | cc-by-nc (c) García-Albéniz, X. et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by-nc/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Càncer colorectal |
dc.subject | Radioteràpia |
dc.subject | Quimioteràpia del càncer |
dc.subject | Cirurgia laparoscòpica |
dc.subject | Estudi de casos |
dc.subject | Colorectal cancer |
dc.subject | Radiotherapy |
dc.subject | Cancer chemotherapy |
dc.subject | Laparoscopic surgery |
dc.subject | Case studies |
dc.title | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |