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dc.contributor.author | Cristelli, M. P. |
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dc.contributor.author | Cofán Pujol, Federico |
dc.contributor.author | Rico, N. |
dc.contributor.author | Trullás Vila, Joan Carles |
dc.contributor.author | Manzardo, Christian |
dc.contributor.author | Agüero Santangelo, Fernando |
dc.contributor.author | Bedini, J. L. |
dc.contributor.author | Moreno Camacho, Ma. Asunción |
dc.contributor.author | Oppenheimer Salinas, Federico |
dc.contributor.author | Miró Meda, José M. |
dc.date | 2017-04-05T14:07:25Z |
dc.date | 2017-04-05T14:07:25Z |
dc.date | 2017-02-10 |
dc.date | 2017-04-05T14:07:25Z |
dc.identifier | 1471-2369 |
dc.identifier | 669001 |
dc.identifier | 28183270 |
dc.identifier.uri | http://hdl.handle.net/2445/109424 |
dc.description | Background Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods Cross-sectional, single center study including adult patients with HIV-infection. Results Four thousand five hundred three patients with HIV-infection (864 women; 19%) were examined. Median age was 45 years (IQR 37-52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82-1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/1.73 m2 for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as "mild reduced GFR" who were classified as "normal function" with CKD-EPI. Using CKD-EPI, it was possible to identify "normal function" (>90 mL/min/1.73 m2) in 73% patients and "mild reduced GFR" (60-89 mL/min/1.73 m2) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m2 with MDRD. Conclusions There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60-89 mL/min/1.73 m2). |
dc.format | 7 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | BioMed Central |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1186/s12882-017-0470-4 |
dc.relation | BMC Nephrology, 2017, vol. 18, num. 1, p. 58 |
dc.relation | https://doi.org/10.1186/s12882-017-0470-4 |
dc.rights | cc-by (c) Cristelli, M.P. et al., 2017 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | VIH (Virus) |
dc.subject | Persones seropositives |
dc.subject | Malalties del ronyó |
dc.subject | Nefrologia |
dc.subject | HIV (Viruses) |
dc.subject | HIV-positive persons |
dc.subject | Kidney diseases |
dc.subject | Nephrology |
dc.title | Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis. |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |