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dc.contributor.author | Corella Piquer, Dolores |
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dc.contributor.author | Sorlí, José V. |
dc.contributor.author | González, José I. |
dc.contributor.author | Ortega Azorín, Carolina |
dc.contributor.author | Fitó Colomer, Montserrat |
dc.contributor.author | Bulló, Mònica |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- |
dc.contributor.author | Ros Rahola, Emilio |
dc.contributor.author | Arós, Fernando |
dc.contributor.author | Lapetra, José |
dc.contributor.author | Gómez Gracia, Enrique |
dc.contributor.author | Serra Majem, Lluís |
dc.contributor.author | Ruiz-Gutiérrez, Valentina |
dc.contributor.author | Fiol Sala, Miguel |
dc.contributor.author | Coltell, Óscar |
dc.contributor.author | Vinyoles, Ernest |
dc.contributor.author | Pintó Sala, Xavier |
dc.contributor.author | Martí, Amelia |
dc.contributor.author | Saiz, Carmen |
dc.contributor.author | Ordovás, José M. |
dc.contributor.author | Estruch Riba, Ramon |
dc.date | 2017-03-20T12:14:57Z |
dc.date | 2017-03-20T12:14:57Z |
dc.date | 2014-01-06 |
dc.date | 2017-03-20T12:14:57Z |
dc.identifier | 1475-2840 |
dc.identifier | 633661 |
dc.identifier | 24393375 |
dc.identifier.uri | http://hdl.handle.net/2445/108628 |
dc.description | BACKGROUND: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain. METHODS: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up. RESULTS: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons. CONCLUSIONS: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. |
dc.format | 13 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | BioMed Central |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1186/1475-2840-13-5 |
dc.relation | Cardiovascular Diabetology, 2014, vol. 13, num. 5, p. 1-13 |
dc.relation | https://doi.org/10.1186/1475-2840-13-5 |
dc.rights | cc-by (c) Corella, Dolores et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Obesitat |
dc.subject | Infart de miocardi |
dc.subject | Diabetis |
dc.subject | Hàbits alimentaris |
dc.subject | Cuina mediterrània |
dc.subject | Assaigs clínics |
dc.subject | Obesity |
dc.subject | Myocardial infarction |
dc.subject | Diabetes |
dc.subject | Food habits |
dc.subject | Mediterranean cooking |
dc.subject | Clinical trials |
dc.title | Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |