dc.contributor.author
Delgado, Julio (Delgado González)
dc.contributor.author
Bielig, Torsten
dc.contributor.author
Bonet, Lizette
dc.contributor.author
Carnero Montoro, Elena
dc.contributor.author
Puente, Xose S.
dc.contributor.author
Colomer Pujol, Dolors
dc.contributor.author
Bosch, Elena
dc.contributor.author
Campo Güerri, Elias
dc.contributor.author
Lozano Soto, Francisco
dc.date.issued
2017-03-03T12:30:38Z
dc.date.issued
2017-04-07T22:01:18Z
dc.date.issued
2016-03-15
dc.date.issued
2017-03-03T12:30:39Z
dc.identifier
https://hdl.handle.net/2445/107804
dc.description.abstract
Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
Blackwell Science
dc.relation
https://doi.org/10.1111/bjh.14037
dc.relation
British Journal of Haematology, 2017, vol. 177,num. 1,p. 147-150
dc.relation
https://doi.org/10.1111/bjh.14037
dc.rights
(c) John Wiley & Sons Ltd, 2016
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Biomedicina)
dc.subject
Leucèmia limfocítica crònica
dc.subject
Receptors cel·lulars
dc.subject
Biologia molecular
dc.subject
Chronic lymphocytic leukemia
dc.subject
Cell receptors
dc.subject
Molecular biology
dc.title
Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/submittedVersion
