Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/105205
| dc.contributor.author | Cordeiro Santanach, Anna |
|---|---|
| dc.contributor.author | Navarro Ponz, Alfons |
| dc.contributor.author | Gaya, Anna |
| dc.contributor.author | Díaz Beyà, Marina |
| dc.contributor.author | González Farré, Blanca |
| dc.contributor.author | Castellano, Joan Josep |
| dc.contributor.author | Fuster, Dolors |
| dc.contributor.author | Martínez, Carmen |
| dc.contributor.author | Martínez Pozo, Antonio |
| dc.contributor.author | Monzó Planella, Mariano |
| dc.date | 2017-01-02T16:21:42Z |
| dc.date | 2017-01-02T16:21:42Z |
| dc.date | 2016-06-14 |
| dc.date | 2017-01-02T16:21:48Z |
| dc.identifier | 1949-2553 |
| dc.identifier | 663236 |
| dc.identifier | 27329591 |
| dc.identifier.uri | http://hdl.handle.net/2445/105205 |
| dc.description | PiwiRNAs, small non-coding RNAs processed by Piwi proteins, are involved in maintaining genome stability in germline cells. Recently, piwiRNA expression has been identified in some tumors. We have examined the potential reactivation of the Piwi/piwiRNA pathway in classical Hodgkin lymphoma (cHL). We found that Piwi proteins and three selected piwiRNAs, including piR-651, were expressed in cHL patients and cell lines, indicating that the Piwi/piwiRNA pathway is active in cHL. Interestingly, low levels of piR-651 were associated with lack of complete response to first-line treatment, as well as shorter disease-free and overall survival in a cohort of 94 cHL patients. At diagnosis, piR-651 was underexpressed in cHL serum samples compared to healthy controls, while after complete remission, piR-651 levels increased to levels similar to healthy controls. This is the first evidence that piwiRNAs are active in tumor and serum samples and impact prognosis in cHL. |
| dc.format | 12 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Impact Journals |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.10015 |
| dc.relation | Oncotarget, 2016, vol. 7, num. 29, p. 46002-46013 |
| dc.relation | https://doi.org/10.18632/oncotarget.10015 |
| dc.rights | cc-by (c) Cordeiro, Anna et al., 2016 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Malaltia de Hodgkin |
| dc.subject | Limfomes |
| dc.subject | Micro RNAs |
| dc.subject | Hodgkin's disease |
| dc.subject | Lymphomas |
| dc.subject | MicroRNAs |
| dc.title | PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma. |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
Documentos relacionados
Otros documentos del mismo autor/a
Cordeiro Santanach, Anna; Navarro Ponz, Alfons; Gaya, Anna; Díaz Beyá, Marina; Gonzalez Farré, Blanca; Castellano, Joan Josep; Fuster, Dolors; Martínez, Carmen; Martínez Pozo, Antonio; Monzó Planella, Mariano
Díaz Beyà, Marina; Brunet, Salut; Nomdedéu Guinot, Josep Francesc; Cordeiro Santanach, Anna; Tormo, Mar; Escoda, Lourdes; Ribera, Josep Maria; Heras, Inmaculada; Gallardo Giralt, David; Bargay, Joan; Queipo de Llano, María Paz; Salamero, Olga; Martí, Josep María; Sampol, Antonia; Pedro, Carme; Hoyos Colell, Montserrat; Pratcorona, Marta; Castellano, Joan Josep; Nomdedeu i Fàbrega, Meritxell; Risueño, Ruth M.; Sierra Gil, Jorge; Monzó Planella, Mariano; Navarro Ponz, Alfons; Esteve Reyner, Jordi; Arnan, Montserrat
Navarro Ponz, Alfons; Tejero Villalba, Rut; Viñolas Segarra, Núria; Cordeiro Santanach, Anna; Marrades Sicart, Ramon Ma.; Fuster, Dolors; Caritg, Oriol; Moisés, Jorge; Muñoz García, Carmen; Molins López-Rodó, Laureano; Ramírez Ruz, J. (José); Monzó Planella, Mariano
Navarro Ponz, Alfons; Muñoz, Carmen; Gaya, Anna; Díaz Beyá, Marina; Gel, Bernat; Tejero Villalba, Rut; Díaz, Tania; Martínez Pozo, Antonio; Monzó Planella, Mariano
Diaz, Tania; Navarro Ponz, Alfons; Ferrer, Gerard; Gel, Bernat; Gaya, Anna; Artells i Prats, Rosa; Bellosillo, Beatriz; Garcia-Garcia, Mar; Serrano, Sergi; Martínez Pozo, Antonio; Monzó Planella, Mariano