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| dc.contributor.author | Abulí, Anna |
|---|---|
| dc.contributor.author | Castells Garangou, Antoni |
| dc.contributor.author | Bujanda, Luis |
| dc.contributor.author | Lozano Salvatella, Juan José |
| dc.contributor.author | Bessa i Caserras, Xavier |
| dc.contributor.author | Hernández-Munain, Cristina |
| dc.contributor.author | Álvarez Urturi, Cristina |
| dc.contributor.author | Pellisé Urquiza, Maria |
| dc.contributor.author | Esteban-Jurado, Clara |
| dc.contributor.author | Hijona, Elizabeth |
| dc.contributor.author | Burón, Andrea |
| dc.contributor.author | Macià, Francesc |
| dc.contributor.author | Grau Cano, J. (Jaume) |
| dc.contributor.author | Guayta, Rafael (Guayta Escolies) |
| dc.contributor.author | Castellví Bel, Sergi |
| dc.contributor.author | Andreu, Montserrat |
| dc.contributor.author | Trilla García, Antoni |
| dc.contributor.author | PROCOLON Research Group |
| dc.date | 2016-11-30T09:34:27Z |
| dc.date | 2016-11-30T09:34:27Z |
| dc.date | 2016-04-14 |
| dc.date | 2016-11-30T09:34:32Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 664539 |
| dc.identifier | 27078840 |
| dc.identifier.uri | http://hdl.handle.net/2445/104289 |
| dc.description | Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population. |
| dc.format | 12 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0153084 |
| dc.relation | PLoS One, 2016, vol. 11, num. 4, p. e0153084 |
| dc.relation | https://doi.org/10.1371/journal.pone.0153084 |
| dc.rights | cc-by (c) Abulí, Anna et al., 2016 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Càncer colorectal |
| dc.subject | Genètica humana |
| dc.subject | Estudi de casos |
| dc.subject | Mutació (Biologia) |
| dc.subject | Colonoscòpia |
| dc.subject | Colorectal cancer |
| dc.subject | Human genetics |
| dc.subject | Case studies |
| dc.subject | Mutation (Biology) |
| dc.subject | Colonoscopy |
| dc.title | Genetic Variants Associated with Colorectal Adenoma Susceptibility |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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