dc.contributor
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor
Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables
dc.contributor.author
Llorens Domenjó, Elena
dc.contributor.author
Valle Mendoza, Luis Javier del
dc.contributor.author
Puiggalí Bellalta, Jordi
dc.date.issued
2015-07-01
dc.identifier
Llorens, E., del Valle, LJ., Puiggali, J. Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs. "Macromolecular research", 1 Juliol 2015, vol. 23, núm. 7, p. 636-648.
dc.identifier
https://hdl.handle.net/2117/103940
dc.identifier
10.1007/s13233-015-3082-5
dc.description.abstract
Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.
dc.description.abstract
Peer Reviewed
dc.description.abstract
Postprint (author's final draft)
dc.format
application/pdf
dc.relation
http://link.springer.com/article/10.1007%2Fs13233-015-3082-5
dc.relation
info:eu-repo/grantAgreement/MINECO/1PE/MAT2012-36205
dc.rights
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.subject
Àrees temàtiques de la UPC::Enginyeria química
dc.subject
Biomedical materials
dc.subject
Electrospinning
dc.subject
Polylactic acid
dc.subject
electrospinning
dc.subject
dual drug-release
dc.subject
poly(lactic acid)
dc.subject
packaging materials
dc.subject
poly(l-lactide)
dc.subject
crystallization
dc.subject
Materials biomèdics
dc.subject
Àcid polilàctic
dc.title
Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
