α-Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes

Abstract

A highly modular technique that streamlines the synthesis of α-difluoroalkylated amines from benzyl amines and trifluoromethylarenes has been developed. This protocol demonstrates remarkable operational simplicity, excellent chemoselectivity, and wide applicability, including with advanced synthetic intermediates, thus providing a novel pathway to access medicinally-relevant α-difluoroalkylated amines from readily available and simple precursors.