dc.contributor.author |
Jannati, Ali |
dc.contributor.author |
Fried, P. J. |
dc.contributor.author |
Block, G. |
dc.contributor.author |
Oberman, L. M. |
dc.contributor.author |
Rotenberg, Alexander |
dc.contributor.author |
Pascual Leone, Álvaro |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/222793 |
dc.identifier |
urn:10.3389/fnins.2019.00447 |
dc.identifier |
urn:oai:ddd.uab.cat:222793 |
dc.identifier |
urn:scopus_id:85068567265 |
dc.identifier |
urn:articleid:1662453Xv13nMAYp447 |
dc.identifier |
urn:pmid:31156361 |
dc.identifier |
urn:pmc-uid:6533847 |
dc.identifier |
urn:pmcid:PMC6533847 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6533847 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Frontiers in Neuroscience ; Vol. 13 Núm. MAY (2019), p. 447 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
APOE |
dc.subject |
BDNF |
dc.subject |
Continuous theta-burst stimulation |
dc.subject |
Plasticity |
dc.subject |
Reliability |
dc.subject |
Transcranial magnetic stimulation |
dc.title |
Test-retest reliability of the effects of continuous theta-burst stimulation |
dc.type |
Article |
dc.description.abstract |
Objectives: The utility of continuous theta-burst stimulation (cTBS) as index of cortical plasticity is limited by inadequate characterization of its test-retest reliability. We thus evaluated the reliability of cTBS aftereffects, and explored the roles of age and common single-nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes. Methods: Twenty-eight healthy adults (age range 21-65) underwent two identical cTBS sessions (median interval = 9.5 days) targeting the motor cortex. Intraclass correlation coefficients (ICCs) of the log-transformed, baseline-corrected amplitude of motor evoked potentials (ΔMEP) at 5-60 min post-cTBS (T5-T60) were calculated. Adjusted effect sizes for cTBS aftereffects were then calculated by taking into account the reliability of each cTBS measure. Results: ΔMEP at T50 was the most-reliable cTBS measure in the whole sample (ICC = 0.53). Area under-the-curve (AUC) of ΔMEPs was most reliable when calculated over the full 60 min post-cTBS (ICC = 0.40). cTBS measures were substantially more reliable in younger participants (< 35 years) and in those with BDNF Val66Val and APOE ϵ4-genotypes. Conclusion: CTBS aftereffects are most reliable when assessed 50 min post-cTBS, or when cumulative ΔMEP measures are calculated over 30-60 min post-cTBS. Reliability of cTBS aftereffects is influenced by age, and BDNF and APOE polymorphisms. Reliability coefficients are used to adjust effect-size calculations for interpretation and planning of cTBS studies. |