Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia

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Title:	Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
Author:	Gersner, Roman; Paredes, Carmen; Hameed, Mustafa Q.; Dhamne, Sameer C.; Pascual Leone, Álvaro; Rotenberg, Alexander
Abstract:	Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired-pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS-EMG detects dose-dependent CE in rats anesthetized with continuous intravenous propofol. Motor-evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS-derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS-EMG enables real-time markers of target engagement by anesthetics that may be incorporated into an automated device
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Uri:	https://ddd.uab.cat/record/226266