Title:
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Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals
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Author:
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Magri, Giuliana; Comerma, Laura; Pybus, Marc; Sintes, Jordi; Lligé, David; Segura Garzón, Daniel; Bascones, Sabrina; Yeste, Ada; Grasset, Emilie K.; Gutzeit, Cindy; Uzzan, Mathieu; Ramanujam, Meera; Van Zelm, Menno C.; Albero-González, Raquel; Vazquez, Ivonne; Iglesias, Mar; Serrano, Sergi; Márquez, Lucía; Mercadé, Elena; Mehandru, Saurabh; Cerutti, Andrea
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Abstract:
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Altres ajuts: European Research Council grant no. ERC-2011-ADG-20110310 |
Abstract:
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Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM + plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM + B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA + B cells, memory IgM + B cells were related to some IgA + clonotypes and switched to IgA in response to T cell-independent or T cell-dependent signals. These signals induced abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded commensals. Bacteria recognized by human SIgM were dually coated by SIgA and showed increased richness and diversity compared to IgA-only-coated or uncoated bacteria. Thus, SIgM may emerge from pre-existing memory rather than newly activated naive IgM + B cells and could help SIgA to anchor highly diverse commensal communities to mucus. Magri et al. found that the human gut includes a large memory IgM + B cell repertoire clonally related to plasma cells mounting SIgM responses against mucus-embedded commensals co-targeted by SIgA. Dually coated bacteria are detected in humans but not mice and show increased diversity and richness compared to SIgA-only-coated or uncoated bacteria. |
Publication date:
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2021-09-10 |
Subject(s):
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-Human -IgM -IgA -Gut -Mucosa -Memory B cells -Plasma cells -Repertoire -Microbiota |
Rights:
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open access
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Document type:
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Article |
Published by:
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Uri:
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https://ddd.uab.cat/record/186295
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