| Title: | Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals |
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| Author: | Magri, Giuliana; Comerma, Laura; Pybus, Marc; Sintes, Jordi; Llige, David; Segura Garzón, Daniel; Bascones, Sabrina; Yeste, Ada; Grasset, Emilie K.; Gutzeit, Cindy; Uzzan, Mathieu; Ramanujam, Meera; Van Zelm, Menno C.; Albero González, Raquel; Vazquez, Ivonne; Iglesias, Mar; Serrano, Sergi; Márquez, Lucía; Mercadé, Elena; Mehandru, Saurabh; Cerutti, Andrea |
| Abstract: | Altres ajuts: European Research Council grant no. ERC-2011-ADG-20110310 |
| Abstract: | Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM + plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM + B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA + B cells, memory IgM + B cells were related to some IgA + clonotypes and switched to IgA in response to T cell-independent or T cell-dependent signals. These signals induced abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded commensals. Bacteria recognized by human SIgM were dually coated by SIgA and showed increased richness and diversity compared to IgA-only-coated or uncoated bacteria. Thus, SIgM may emerge from pre-existing memory rather than newly activated naive IgM + B cells and could help SIgA to anchor highly diverse commensal communities to mucus. Magri et al. found that the human gut includes a large memory IgM + B cell repertoire clonally related to plasma cells mounting SIgM responses against mucus-embedded commensals co-targeted by SIgA. Dually coated bacteria are detected in humans but not mice and show increased diversity and richness compared to SIgA-only-coated or uncoated bacteria. |
| Subject(s): | -Human -IgM -IgA -Gut -Mucosa -Memory B cells -Plasma cells -Repertoire -Microbiota |
| Rights: | open access
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| Document type: | Article |
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| Uri: | https://ddd.uab.cat/record/186295 |
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