dc.contributor.author |
Amorós-Figueras, Gerard |
dc.contributor.author |
Jorge, Esther |
dc.contributor.author |
García Sánchez, Tomás |
dc.contributor.author |
Bragos, Ramon |
dc.contributor.author |
Rosell Ferrer, Javier |
dc.contributor.author |
Cinca, Juan |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2016 |
dc.identifier |
https://ddd.uab.cat/record/185983 |
dc.identifier |
urn:10.3389/fphys.2016.00389 |
dc.identifier |
urn:oai:ddd.uab.cat:185983 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/ff95e73f-03b2-44d3-adf2-19d068370352 |
dc.identifier |
urn:pmid:27630580 |
dc.identifier |
urn:scopus_id:84988569333 |
dc.identifier |
urn:pmc-uid:5006502 |
dc.identifier |
urn:pmcid:PMC5006502 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:5006502 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III FIS-PI13-00765 |
dc.relation |
Instituto de Salud Carlos III DTS-15-00099 |
dc.relation |
Instituto de Salud Carlos III RIC-RD12-0042-0002] |
dc.relation |
Frontiers in physiology ; Vol. 7 (august 2016) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Healed myocardial infarction |
dc.subject |
Myocardial electrical impedance |
dc.subject |
Hemodynamics |
dc.subject |
Novel bioimpedance device |
dc.subject |
Swine |
dc.title |
Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Fundació "La Marató" de TV3 [20150830] |
dc.description.abstract |
Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but this is not known. This study aimed to characterize the local changes of systolic-diastolic myocardial impedance in a healed myocardial infarction model. Six pigs were successfully submitted to 150 min of left anterior descending (LAD) coronary artery occlusion followed by reperfusion. 4 weeks later, myocardial impedance spectroscopy (1-1000 kHz) was measured at different infarction sites. The electrocardiogram, left ventricular (LV) pressure, LV dP/dt, and aortic blood flow (ABF) were also recorded. A total of 59 LV tissue samples were obtained and histopathological studies were performed to quantify the percentage of fibrosis. Samples were categorized as normal myocardium (<10% fibrosis), heterogeneous scar (10-50%) and dense scar (>50%). Resistivity of normal myocardium depicted phasic changes during the cardiac cycle and its amplitude markedly decreased in dense scar (18 ± 2 Ω·cm vs. 10 ± 1 Ω·cm, at 41 kHz; P < 0.001, respectively). The mean phasic resistivity decreased progressively from normal to heterogeneous and dense scar regions (285 ± 10 Ω·cm, 225 ± 25 Ω·cm, and 162 ± 6 Ω·cm, at 41 kHz; P < 0.001 respectively). Moreover, myocardial resistivity and phase angle correlated significantly with the degree of local fibrosis (resistivity: r = 0.86 at 1 kHz, P < 0.001; phase angle: r = 0.84 at 41 kHz, P < 0.001). Myocardial infarcted regions with greater fibrotic content show lower mean impedance values and more depressed systolic-diastolic dynamic impedance changes. In conclusion, this study reveals that differences in the degree of myocardial fibrosis can be detected in vivo by local measurement of phasic systolic-diastolic bioimpedance spectrum. Once this new bioimpedance method could be used via a catheter-based device, it would be of potential clinical applicability for the recognition of fibrotic tissue to guide the ablation of atrial or ventricular arrhythmias. |