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Insights into the alkaline degradation of oxidized chondroitin sulfate: Implications in Schiff base formation for hydrogel fabrication
Chondroitin sulfate (CS) shows great promise for hydrogels and scaffolds in tissue engineering due to its biocompatibility and compressive strength. However, its chemical structure limits its use, necessitating modifications ...
Ultra-sensitive UHPLC-MS/MS method for simultaneous quantification of 31 neurochemicals in zebrafish larvae and brain
The precise determination of neurotransmitters and their metabolites in biological matrices is critical for research on neurological disorders, including those originated by the exposure to neurotoxic chemicals. This study ...
Virtual vs Human: Comparing Persuasive Factors in Influencer Marketing Campaigns
This chapter explores the evolving landscape of influencer marketing with the advance of virtual influencers—AI-powered, computer-generated characters designed to emulate human influencers. As traditional advertising faces ...
Impact of strategic capabilities on digital transformation success and firm performance: theory and empirical evidence
What is needed for organisations to succeed in digital transformation, and what is its advantage? Motivated by the ongoing high amount of failing digital transformations, this study identifies necessary predictors and ...
3D Printing of Silicone Organogel Elastomers for Structured Soft Biomaterials
Creating customizable soft medical implants and devices tailored to patient-specific anatomy represents a significant challenge in healthcare, requiring 3D-printable materials with viscoelastic properties similar to those ...
A comprehensive fatigue analysis of high performance polyetherimide parts fabricatedusing extrusion-based additive manufacturing
This paper investigates the fatigue behavior of high-performance polyetherimide components manufactured via MEX-AM, focusing on the influence of key process parameters. Thirty configurations were tested under four load ...
From Françafrique to Chinafrica? Ecologically unequal exchange, neocolonialism, and environmental conflicts in Africa
Africa stands out as the continent where the legacies of colonialism and the ongoing dynamics of neo- and post-colonialism are felt most profoundly. In its role as the primary global supplier of raw materials, and with the ...
Achieving 17-4 PH parts with comparable performance to high-investment technologies through a multivariable Doehlert design optimization and material extrusion
Purpose: This study aims to optimize Metal Additive Manufacturing (MAM) via Material Extrusion (MEX) using desktop equipment to produce high-performance 17-4 PH stainless steel parts. This research seeks to address the ...
Exploring the Role of Artificial Intelligence in Precision Photonics: A Case Study on Deep Neural Network-Based fs Laser Pulsed Parameter Estimation for MoOx Formation
Ultrafast pulsed laser technology presents unique challenges and opportunities in material processing and characterization for precision photonics. Herein, an experiment is conducted involving the use of an ultrafast pulsed ...
Assessing neurological and cardiovascular effects caused by pharmaceuticals in river water: Insights from Daphnia magna and Danio rerio embryos
Pharmaceutical residues in surface waters are an emerging environmental and public health issue, yet their biological impacts on aquatic life remain poorly understood. This study presents a cost-effective bioanalytical ...
The Politics of Rootedness: On Simone Weil and George Orwell
Simone Weil and George Orwell both reflected—at a time when liberalism and Christianity were being challenged—on how to provide rootedness to societies and how to provide a moral anchoring and collective inspiration. The ...
Enhancing Legged Robot Locomotion Through Smooth Transitions Using Spiking Central Pattern Generators
In this work, we propose the integration of a mechanism to enable smooth transitions between different locomotion patterns in a hexapod robot. Specifically, we utilize a spiking neural network (SNN) functioning as a Central ...
Automated tool for cylindrical glass container blow and blow mold design
The manufacture of perfumery bottles using the blow-and-blow technique necessitates iterative design and production of intermediate or preparation molds to achieve an appropriate thickness distribution. Designers seek a ...
Single particle ICP-MS: a tool for the characterization of gold nanoparticles in nanotheranostics applications
Nanotheranostics aims to perform a premature and non-invasive diagnosis combined with therapy focused on the specific place where the disease is by using nanomaterials. To evaluate the ability to penetrate and retain the ...
Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase
UDP-galactose 4-epimerases (Gal4Es) catalyze the inversion of the 4-hydroxyl configuration of a sugar moiety from an NDP-sugar through a three-step process: oxidation, rotation and reduction. Despite extensive biochemical ...
N-Acetylcysteine-Amide Protects Against Acute Acrylamide Neurotoxicity in Adult Zebrafish
Acrylamide (ACR) is a potent neurotoxicant that disrupts cellular redox homeostasis by depleting reduced glutathione (GSH) and inducing oxidative stress. Despite its well-characterized mechanism, no effective treatments ...
An Orthogonally Clickable and Stimuli-Responsive Poly(β-amino ester) for the Co-delivery of Doxorubicin and BCL-2 siRNA
A potent drug delivery system (DDS) based on poly(β-amino ester)s (pBAEs) to tackle multidrug resistance (MDR) in lung cancer by codelivering siRNA targeting antiapoptotic BCL-2 and doxorubicin (DOX) has been prepared. ...
What Makes Help Helpful? Some Thoughts on Ethics of Solidarity Through George Orwell’s Writings
Organisations that offer personal services, whether this be a law firm or a hospital, may be extremely good at offering technical solutions to people, but when it comes to offering recognition, this is much more of a ...
Polymer-based coating of adeno-associated viral particles as a new strategy to evade immune response for DMD treatment
Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the dystrophin gene, leading to progressive muscle degeneration. Gene therapy using adeno-associated virus (AAV) vectors holds potential ...
