IQS: Envíos recientes
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Subir a por aire (1939), o la infrapolítica según George Orwell
George Orwell expuso los mecanismos de opresión del individuo bajo los regímenes totalitarios. Su influencia, tanto en la teoría política como en la vida cotidiana, ha sido indiscutible. Sin embargo, otra novela suya, ...
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin
Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and ...
In Vivo Retargeting of Poly(beta aminoester) (OM-PBAE) Nanoparticles is Influenced by Protein Corona
One of the main bottlenecks in the translation of nanomedicines from research to clinics is the difficulty in designing nanoparticles actively vectorized to the target tissue, a key parameter to ensure efficacy and safety. ...
Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide
Endothelial cells (ECs) are an important target for therapy in a wide range of diseases, most notably atherosclerosis. Developing efficient nanoparticle (NP) systems that deliver RNA interference (RNAi) drugs specifically ...
9-Aryl-phenalenones: Bioinspired thermally reversible photochromic compounds for photoswitching applications in the pico-to milliseconds range
Ultrafast photochromic molecules are being actively investigated to meet the demand for fast optical switching systems. Inspired on the irreversible cyclization of 9-phenylphenalenone plant metabolites to yield highly-coloured ...
NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen
A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular probe Singlet Oxygen ...
Surface plasmon resonance effect on laser trapping and swarming of gold nanoparticles at an interface
Laser trapping at an interface is a unique platform for aligning and assembling nanomaterials outside the focal spot. In our previous studies, Au nanoparticles form a dynamically evolved assembly outside the focus, leading ...
Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of ...
Additive Manufacturing Gyroid Structures Used as Crash Energy Management
Gyroid-like structures are promising in terms of energy absorption levels. Due to additive manufacturing, they can now be manufactured and verified for different functions. In this article, it has been proven that a Gyroid ...
Computational Fluid Dynamic study of gas mixtures in a Non-Thermal Plasma reactor for CO2 conversion with Argon as diluent gas
CO2 utilization has been an emerging technology of increasing global interest due to its direct impact in limiting greenhouse gas emissions. In this contribution, the fluid dynamic behavior of a CO2 conversion ...
Quality-by-design as the pharmaceutical innovation paradigm: mapping the field and proposing a conceptual framework
Quality management (QM) and innovation practices are essential for business competitiveness, yet they often conflict when striving for radical advancements within complex innovation ecosystems. Amid this debate, the concept ...
Development and characterization of electrochemical hydrogen sensors using different fabrication techniques
Tritium Breeding Modules (TBMs) aim to demonstrate tritium self-sufficiency for future fusion reactors. These modules operate at high temperatures, requiring stable, real-time and high-temperature monitoring of the tritium ...
Fluid Modeling of a Non-Thermal Plasma with Dielectric Barrier Discharge and Argon as a Diluent Gas
Non-thermal plasma (NTP) conversion applications have become an emerging technology of increasing global interest due to their particular ability to perform at atmospheric pressure and ambient temperature. This study focuses ...
Enhancing Liquid State Machine Classification Through Reservoir Separability Optimization Using Swarm Intelligence and Multitask Learning
The Liquid State Machine (LSM) framework addresses supervised learning tasks involving spatio-temporal data streams. It relies on a randomly created, untrained Spiking Recurrent Neural Network (SRNN), called the “liquid,” ...
The Use of a Penta-Deuterophenyl Substituent to Improve the Metabolic Stability of a Tyrosine Kinase Inhibitor
In cases in which a rapid metabolism is the cause of an unfavorable pharmacokinetic profile, it is important to determine the Sites of Metabolism (SoMs) of a molecule to introduce the necessary modifications to improve the ...
La secularización del pecado original y la autorreforma del humanismo
The humanist project of modernity required that there be no original sin, as Christianity maintained, that prevented us from achieving ever greater quotas of freedom and progress. Thus, the Enlightenment spoke of the social ...
Lithium sensors based on Li6La3Ta1.5Y0.5O12 and Li6BaLa2Ta2O12 garnet electrolytes for molten lead alloys
The development of effective breeding blankets is crucial to the success of future fusion reactors. One of the main liquid breeding candidates is molten eutectic Pb-Li. In this environment, it is essential to control lithium ...
A Tribute to Ullmann’s Work: Expanding Copper Coil Reactor Applications toward the Hydroxylation of Aryl Bromides
Copper coil flow reactors represent an economic, abundant, and durable platform for conducting copper-catalyzed reactions. These have been used in the past for Ullmann-type reactions starting from aryl iodides. However, ...
Li6La3Ta1.5Y0.5O12 solid-state lithium sensor for molten alloys
Different breeding blankets are proposed for tritium generation in nuclear fusion reactors. Some of the proposed strategies are based on the molten eutectic alloy Lithium - Lead. Since lithium will be consumed, this alloy's ...
ZnO Sintering aid effect on Proton Conductivity of BaCe0.6Zr0.3Y0.1O3-δ electrolyte for Hydrogen sensors
Proton-conducting solid-state electrolytes, including perovskite-type materials, hold promise for hydrogen sensor development. These sensors leverage the proton conductivity of such materials to detect hydrogen gas ...
