IQS: Recent submissions
Now showing items 221-240 of 794
Regulation of mitochondrial apoptosis via siRNA-loaded metallo-alginate hydrogels: A localized and synergistic antitumor therapy
Preventing relapse after resection of a primary tumor continues to be an unmet clinical need. Development of adjuvant biomaterials with the capacity to kill residual cancer cells after tumor resection is of clinical ...
Co-evaluación de competencias en el proyecto final de carrera: aplicación a la titulación de administración y dirección de empresas
El presente trabajo muestra una metodología basada en la recolección de información de estudiantes y tutores relacionados con las competencias que se desarrollan en el Proyecto Final de Carrera en la titulación de ...
Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment
The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium strains calls for new strategies capable of improving the bioavailability of antimalarials, especially of those whose lipophilic ...
Dedifferentiated human articular chondrocytes redifferentiate to a cartilage-like tissue phenotype in a poly(ε-caprolactone)/self-assembling peptide composite scaffold
Adult articular cartilage has a limited capacity for growth and regeneration and, with injury, new cellular or biomaterial-based therapeutic platforms are required to promote repair. Tissue engineering aims to produce ...
Nucleic acid-loaded poly(beta-aminoester) nanoparticles for cancer nano-immuno therapeutics
Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients’ quality of life. However, realizing the full potential of immunotherapy in clinical practice ...
Assessing the pharmaceutical residues as hotspots of the main rivers of Catalonia, Spain
The global increase in pharmaceutical consumption, driven by factors such as aging populations and chronic diseases, has raised concerns regarding the environmental impact of pharmaceutical contaminants. Europe, and more ...
Current progress in bionanomaterials to modulate the epigenome
Recent advances in genomics during the 1990s have made it possible to study and identify genetic and epigenetic responses of cells and tissues to various drugs and environmental factors. This has accelerated the number of ...
Unravelling the role of individual components in pBAE/polynucleotide polyplexes in the synthesis of tailored carriers for specific applications: on the road to rational formulations
Oligopeptide end–modified poly(β-amino ester)s (OM-pBAEs) offer a means for the effective implementation of gene therapeutics in the near future. A fine-tuning of OM-pBAEs to meet application requirements is achieved by ...
Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70
Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. Such structures, ...
Structural analysis of an automotive interior system: practical learning in the context of the new EHEA
At the IQS School of Engineering, practices has been implemented that bring students to the industrial environment through real cases. This action is in accordance with the philosophy of the European Higher Education Area ...
Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives
A new family of antifibrinolytic drugs has been recently discovered, combining a triazole moiety, an oxadiazolone, and a terminal amine. Two of the molecules of this family have shown activity that is greater than or similar ...
Zwitterionic 3D-printed non-immunogenic stealth microrobots
Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection ...
Electrochemical impedance spectroscopy evaluation of nonthermal plasma restoration for ductile metals in cultural heritage artifacts
Despite the large number of studies devoted to understanding the degradation process of ductile metals in cultural heritage, there is still a lack of consolidated protocols for their restoration. Traditional restorations ...
The Role of Work Motivation Based on Values in Employee’s Retention in the 21st Century
Organizations in the 21th century have to address the problem of employee’s retention as it has direct and indirect costs for the organisation. In regards to this issue several theories have emerged pointing out the strong ...
Engineered microtissues for the bystander therapy against cancer
Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires ...
Do folate-receptor targeted liposomal photosensitizers enhance photodynamic therapy selectivity?
One of the current goals in photodynamic therapy research is to enhance the selective targeting of tumor cells in order to minimize the risk and the extension of unwanted side-effects caused by normal cell damage. Special ...
Comparative Analysis of Chemical, Thermal, and Mechanical Post-Process of Fused Filament Fabricated Polyetherimide Parts for Surface Quality Enhancement
Additive manufacturing technologies are increasingly being used in production systems because they shorten product development time and production cost, but surface integrity remains a limitation to meet the standards set ...
Dynamic Combinatorial Optimization of In Vitro and In Vivo Heparin Antidotes
Heparin-like macromolecules are widely used in clinics as anticoagulant, antiviral, and anticancer drugs. However, the search of heparin antidotes based on small synthetic molecules to control blood coagulation still remains ...
