Recerca: Enviaments recents
Ara mostrant els elements 541-560 de 4367
Microstructure and mechanical properties of TiN/CrN multilayer coatings deposited in an industrial-scale HiPIMS system
TiN/CrN multilayer coatings of varying bilayer period (Ʌ) were deposited in an industrial-scale deposition plant by means of reactive high power impulse magnetron sputtering. By alternately sputtering titanium and chromium ...
High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024
Protein kinases are highly relevant drug targets, yet a significant fraction of the human kinome remains underexplored. Highly potent and selective small-molecule inhibitors used as chemical probes are invaluable tools for ...
miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes, immune dysregulation, and abnormal epidermal differentiation. Its pathogenesis involves complex interactions among ...
Nanocarriers for Combination Therapy in Pancreatic Ductal Adenocarcinoma: A Comprehensive Review
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers worldwide, characterized by late diagnosis, aggressive progression, and poor response to conventional monotherapies. Combination therapies have ...
Revolutionizing rheumatoid arthritis therapy: the potential of lipid nanocarriers
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovitis, systemic inflammation and autoantibodies, leading to joint damage and disability. RA pathogenesis is characterized by a dysregulated ...
The Influence of Gender Discrimination and Gender Equality on Corporate Tax Aggressiveness
In this paper, we examine whether gender diversity on board audit committees promotes socially responsible corporate tax behavior by analyzing the influence of female directors on aggressive tax strategies. We explore this ...
Polar π stacking for metal-free near, remote, and ultra-remote C–H coupling with aryliodanes
We introduce a C–H coupling process in which an aromatic C–I position serves as trampoline for targeting various aromatic C–H positions. The reaction is set in motion by an interaction between the λ3-iodane ArI(OAc)2 and ...
Go for Gold: Development of a Scalable Synthesis of [1-(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors
Covalent approaches have resurged in drug discovery and chemical biology during the last decade. So-called targeted covalent inhibitors typically show a strong and persistent drug–target interaction as well as a high degree ...
Development of simplified poly(β-aminoester)-zwitterion nanovehicles for transfection of cancer cells and improved gene delivery across a cell-based model of the blood-brain barrier
Although nucleotide-based therapeutics hold promise for a variety of diseases, their clinical application is limited because of low stability and poor bioavailability. Among non-viral gene delivery vectors, poly(β-aminoester)s ...
The Lehtinen–Pirjola method modified for efficient modelling of geomagnetically induced currents in multiple voltage levels of a power network
The need for accurate assessment of the geomagnetic hazard to power systems is driving a requirement to model geomagnetically induced currents (GIC) in multiple voltage levels of a power network. The Lehtinen–Pirjola method ...
From risk to action: how perceived risks and cultural dynamics drive surplus food purchases in China and Spain
Surplus food retailing reduces waste and supports food security; however, cultural differences critically shape consumer behaviors. Combining the theory of planned behavior and risk theory, this study compares the drivers ...
Eco-Friendly Mechanochemical Fabrication of Polypyrrole/Ag-ZnO Heterostructures for Enhanced Photocatalytic Degradation of Methyl Orange
A Ppy/Ag-ZnO catalyst was successfully synthesized at room temperature using a novel, green methodology. It involves a mechanically assisted metathesis reaction. The Ppy/Ag-ZnO catalyst was analyzed via X-ray diffraction ...
Dating Violence in Chilean Adolescents: meanings, ways of manifesting and directionality, from a gender and inclusivity perspective
Background Dating violence (DV) is recognized as a public health problem, so there is still a need to delve deeper into the different perceptions of adolescents about DV, specifically considering the diversity of gender ...
BioFace3D: An end-to-end open-source software for automated extraction of potential 3D facial biomarkers from MRIscans
Background and Objectives: Facial dysmorphologies have emerged as potential critical indicators in the diagnosis and prognosis of genetic, psychotic, and rare disorders. While some conditions present with severe ...
Psychosocial Factors and Sociodemographic Characteristics Associated with Suicidality Risk in Chilean Adolescents
Background: Suicidality in adolescents is a growing concern and is currently a public health issue in Chile and the world. Objective: To determine the association between the risk of suicidality with self-harm, sociodemographic ...
What is a healthy dating relationship and what helps it get there? Perceptions of Chilean adolescents from a gender and inclusivity perspective
Introduction: Relationships are often the focal point of life and can have a positive or a negative impact on a child’s or adolescent’s development, thus understanding the traits of healthy dating relationships may benefit ...
An analysis of barriers faced by women tourism entrepreneurs in Barcelona: employing a feminist ethic of care
Barcelona is an internationally recognised tourism destination and the most alluring place in Spain for entrepreneurship; however, notably women are underrepresented in the entrepreneurial ecosystem. To give voice to ...
Determinants of early smartphone ownership: a research gap in the study of problematic smartphone use in children and adolescents
Over the past decade, a significant body of research has focused on problematic smartphone use and smartphone addiction among children and adolescents. Much of this research focuses on the negative consequences of smartphone ...
Setting the Sustainability Agenda: The Impact of Luxury Brands' SDG-Related Tweets on Consumer Engagement
This study examines luxury market brands' communications related to the sustainable development goals (SDGs) on the social media platform “X,” and their impact on online consumer engagement. Our longitudinal study analyses ...
From mold to mill: StachCel5, a novel thermoalkaliphilic endoglucanase from Stachybotrys chartarum for pulp fiber biorefining
StachCel5, a novel endo-β-1,4-glucanase from Stachybotrys chartarum IBT 7711, was identified through genome mining and exhibited 65 % sequence identity with known glycoside hydrolase family 5 (GH5) cellulases. The gene was ...
