Food and microbiota metabolites associate with cognitive decline in older subjects: A 12-year prospective study 

    González-Domínguez, Raúl; Castellano Escuder, Pol; Carmona Pontaque, Francesc; Lefèvre Arbogast, Sophie; Low, Dorrain Yanwen; Du Preez, Andrea; Ruigrok, Silvie R.; Manach, Claudine; Urpí Sardà, Mireia; Korosi, Aniko; Lucassen, Paul J.; Aigner, Ludwig; Pallàs i Llibería, Mercè, 1964-; Thuret, Sandrine; Samieri, Cécilia; Sànchez, Àlex (Sànchez Pla); Andrés Lacueva, Ma. Cristina (2022-04-01)

    Scope Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results The article studies the long-term ...

    From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 

    Pont Masanet, Caterina; Ginex, Tiziana; Griñán Ferré, Christian; Scheiner, Matthias; Mattellone, Alexia; Martínez, Noemí; Arce, Elsa M.; Soriano-Fernández, Yolanda; Naldi, Marina; De Simone, Angela; Barenys Espadaler, Marta; Gómez Catalán, Jesús; Pérez, Belén; Sabaté Lagunas, Raimon; Andrisano, Vincenza; Loza, María Isabel; Brea, José; Bartolini, Manuela; Bolognesi, Maria Laura; Decker, Michael; Pallàs i Llibería, Mercè, 1964-; Luque Garriga, F. Xavier; Muñoz-Torrero López-Ibarra, Diego (2022-03-14)

    Starting from six potential hits identified in a virtual screening campaign directed to a cryptic pocket of BACE-1, at the edge of the catalytic cleft, we have synthesized and evaluated six hybrid compounds, designed to ...

    Nutrition for the ageing brain: Towards evidence for an optimal diet 

    Vauzour, D.; Camprubi-Robles, Maria; Miquel-Quergoat, Sophie; Andrés Lacueva, Ma. Cristina; Bánáti, Diana; Barberger-Gateau, Pascale; Bowman, Gene L.; Caberlotto, Laura; Clarke, Robert; Hogervorst, Eef; Kiliaan, Amanda J.; Lucca, Ugo; Manach, Claudine; Minihane, Anne-Marie; Mitchell, E.S.; Perneczky, Robert; Perry, Hugh; Roussel, Anne-Marie; Schuermans, J.; Sijben, J.; Spencer, Jeremy P.E.; Thuret, Sandrine; van de Rest, O.; Vandewoude, M.; Wesnes, K.; Willims, R.J.; Williams, R.S.; Ramirez, M. (2020-05-26)

    As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains ...