A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort Study 

    Tor Roca, Alba; Sànchez, Àlex (Sànchez Pla); Korosi, Aniko; Pallàs i Llibería, Mercè, 1964-; Lucassen, Paul J.; Castellano Escuder, Pol; Aigner, Ludwig; González-Domínguez, Raúl; Manach, Claudine; Carmona Pontaque, Francesc; Vegas, Esteban; Helmer, Catherine; Feart, Catherine; Lefèvre Arbogast, Sophie; Neuffer, Jeanne; Lee, Hyunah; Thuret, Sandrine; Andrés Lacueva, Ma. Cristina; Samieri, Cécilia; Urpí Sardà, Mireia (2025-03-17)

    Scope Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score ...

    A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial 

    Del Bo, Cristian; Bernardi, Stefano; Cherubini, Antonio; Porrini, Marisa; Gargari, Giorgio; Hidalgo Liberona, Nicole; González-Domínguez, Raúl; Zamora-Ros, Raul; Peron, Gregorio; Marino, Mirko; Gigliotti, Letizia; Winterbone, Mark S.; Kirkup, Benjamin; Kroon, Paul A.; Andrés Lacueva, Ma. Cristina; Guglielmetti, Simone; Riso, Patrizia (2022-04-14)

    Background & aim: Increased intestinal permeability (IP) can occur in older people and contribute to the activation of the immune system and inflammation. Dietary interventions may represent a potential strategy to reduce ...

    Association between both total baseline urinary and dietary polyphenols and substantial physical performance decline risk in older adults: A 9-year follow-up of the InCHIANTI study 

    Rabassa Bonet, Montserrat; Zamora-Ros, Raul; Andrés Lacueva, Ma. Cristina; Urpí Sardà, Mireia; Bandinelli, Stefania; Ferrucci, Luigi; Cherubini, Antonio (2016-03-14)

    Importance: The decline in physical performance that occurs in many older subjects is a strong predictor of falls, hospitalization, institutionalization and mortality. Polyphenols are bioactive compounds that may play a ...

    Association between dairy products intake and frailty transitions in older adults: The InCHIANTI cohort study 

    Hidalgo Liberona, Nicole; Meroño, Tomás; Zamora-Ros, Raul; Trevisan, Caterina; Fedecostante, Massimiliano; Bandinelli, Stefania; Ferrucci, Luigi; Cherubini, Antonio; Andrés Lacueva, Ma. Cristina (2025-04-23)

    Objective To evaluate the association between dairy products consumption and the probability of frailty transitions in community-dwelling older adults. Design Longitudinal study. Setting and participants We included ...

    Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects 

    Del Bo, Cristian; Martini, Daniela; Bernardi, Stefano; Gigliotti, Letizia; Marino, Mirko; Gargari, Giorgio; Meroño, Tomás; Hidalgo Liberona, Nicole; Andrés Lacueva, Ma. Cristina; Kroon, Paul A.; Cherubini, Antonio; Guglielmetti, Simone; Porrini, Marisa; Riso, Patrizia (2022-03-25)

    Abstract The use of DNA damage as marker of oxidative stress, metabolic dysfunction and age-related diseases is debated. The present study aimed at assessing the level of DNA damage (evaluated as DNA strand-breaks, endogenous ...

    Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study 

    Rabassa Bonet, Montserrat; Zamora-Ros, Raul; Urpí Sardà, Mireia; Bandinelli, Stefania; Ferrucci, Luigi; Andrés Lacueva, Ma. Cristina; Cherubini, Antonio (2016-03-14)

    BACKGROUND: Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. OBJECTIVE: We prospectively evaluated the association between habitual dietary ...

    Bicyclic alfa-iminophosphonates as high affinity imidazoline I2 receptor ligands for Alzheimer's disease 

    Abás Prades, Sònia; Rodríguez-Arévalo, Sergio; Bagan Polonio, Andrea; Griñán Ferré, Christian; Vasilopoulou, Foteini; Brocos-Mosquera, Iria; Muguruza, Carolina; Pérez, Belén; Molins i Grau, Elies; Luque Garriga, F. Xavier; Pérez Lozano, Pilar; Jonghe, Steven de; Daelemans, Dirk; Naesens, Lieve; Brea, José; Loza, María Isabel; Hernández-Hernández, Elena; García-Sevilla, Jesús A.; García-Fuster, M. Julia; Radan, Milica; Djikic, Teodora; Nikolic, Katarina; Pallàs i Llibería, Mercè, 1964-; Callado, Luis F.; Escolano Mirón, Carmen (2020-12-10)

    Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that suffered from neurodegenerative disorders, are orphan from the structural point of view and new I2-IR ligands are urgently required ...

    Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with leaky gut: The MaPLE trial 

    Peron, Gregorio; Gargari, Giorgio; Meroño, Tomás; Miñarro Alonso, Antonio; Vegas Lozano, Esteban; Castellano Escuder, Pol; González-Domínguez, Raúl; Hidalgo Liberona, Nicole; Del Bo, Cristian; Bernardi, Stefano; Kroon, Paul A.; Carrieri, Barbara; Cherubini, Antonio; Riso, Patrizia; Guglielmetti, Simone; Andrés Lacueva, Ma. Cristina (2022-03-17)

    Background &aim: The MaPLE study was a randomized, controlled, crossover trial involving adults 60 y.o. (n ¼ 51) living in a residential care facility during an 8-week polyphenol-rich (PR)-diet. Results from the MaPLE trial ...

    Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial 

    Guglielmetti, Simone; Bernardi, Stefano; Del Bo, Cristian; Cherubini, Antonio; Porrini, Marisa; Gargari, Giorgio; Hidalgo Liberona, Nicole; González-Domínguez, Raúl; Peron, Gregorio; Zamora-Ros, Raul; Winterbone, Mark S.; Kirkup, Benjamin; Kroon, Paul A.; Andrés Lacueva, Ma. Cristina; Riso, Patrizia (2020-05-14)

    : During aging, alterations of the intestinal microbial ecosystem can occur contributing to immunosenescence, inflamm-aging and impairment of intestinal barrier function (increased intestinal permeability; IP). In the ...

    Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects 

    Martini, Daniela; Bernardi, Stefano; Del Bo, Cristian; Hidalgo Liberona, Nicole; Zamora-Ros, Raul; Tucci, Massimiliano; Cherubini, Antonio; Porrini, Marisa; Gargari, Giorgio; González-Domínguez, Raúl; Peron, Gregorio; Kirkup, Benjamin; Kroon, Paul A.; Andrés Lacueva, Ma. Cristina; Guglielmetti, Simone; Riso, Patrizia (2020-10-29)

    Abstract: The evaluation of food intake in older subjects is crucial in order to be able to verify adherence to nutritional recommendations. In this context, estimation of the intake of specific dietary bioactives, such ...

    Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications. 

    Peron, Gregorio; Hidalgo Liberona, Nicole; González-Domínguez, Raúl; Garcia Aloy, Mar; Guglielmetti, Simone; Bernardi, Stefano; Kirkup, Benjamin; Kroon, Paul A.; Cherubini, Antonio; Riso, Patrizia; Andrés Lacueva, Ma. Cristina (2020-05-26)

    The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect ...

    Habitual Nut Exposure, Assessed by Dietary and Multiple Urinary Metabolomic Markers, and Cognitive Decline in Older Adults: The InCHIANTI Study. 

    Rabassa Bonet, Montserrat; Zamora-Ros, Raul; Palau Rodríguez, Magalí; Tulipani, Sara; Miñarro Alonso, Antonio; Bandinelli, Stefania; Ferrucci, Luigi; Cherubini, Antonio; Andrés Lacueva, Ma. Cristina (2020-07-03)

    Scope: The association between self-reported dietary intake and urinary metabolomic markers of habitual nut exposure with cognitive decline over a 3-year follow-up in an older Italian population is prospectively evaluated. ...

    Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability 

    Hidalgo Liberona, Nicole; González-Domínguez, Raúl; Vegas Lozano, Esteban; Riso, Patrizia; Del Bo, Cristian; Bernardi, Stefano; Peron, Gregorio; Guglielmetti, Simone; Gargari, Giorgio; Kroon, Paul A.; Cherubini, Antonio; Andrés Lacueva, Ma. Cristina (2021-01-28)

    Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these ...

    Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives 

    Bernardi, Stefano; Del Bo, Cristian; Guglielmetti, Simone; Gargari, Giorgio; Cherubini, Antonio; Kroon, Paul A.; Kirkup, Benjamin; Hidalgo Liberona, Nicole; Peron, Gregorio; González-Domínguez, Raúl; Andrés Lacueva, Ma. Cristina; Riso, Patrizia (2022-04-14)

    In recent years, research has been focusing on strategies to counteract inflammatory processes and age-related diseases(1). During ageing, a low-grade systemic inflammation is often associated to an altered intestinal ...

    Plasma polyunsaturated fatty acids and age-related physical performance decline 

    Abbatecola, Angela M.; Cherubini, Antonio; Guralnik, Jack M.; Andrés Lacueva, Ma. Cristina; Ruggiero, Carmelinda; Maggio, Marcello; Bandinelli, Stefania; Paolisso, Giuseppe; Ferrucci, Luigi (2015-12-22)

    Due to supporting evidence that dietary patterns may have a significant role in the maintenance of good physical performance with aging, we tested whether plasma fatty acids, saturated fatty acids (SFA), and polyunsaturated ...

    Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk 

    Valls Pedret, Cinta; Lamuela Raventós, Rosa Ma.; Medina Remón, Alexander; Quintana, Melibea; Corella Piquer, Dolores; Pintó Sala, Xavier; Martínez-González, Miguel Ángel, 1957-; Estruch Riba, Ramon; Ros Rahola, Emilio (2013-06-04)

    Brain oxidative processes play a major role in age-related cognitive decline, thus consumption of antioxidant-rich foods might help preserve cognition. Our aim was to assess whether consumption of antioxidant-rich foods ...

    The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial 

    Meroño, Tomás; Peron, Gregorio; Gargari, Giorgio; González-Domínguez, Raúl; Miñarro Alonso, Antonio; Vegas Lozano, Esteban; Hidalgo Liberona, Nicole; Del Bo, Cristian; Bernardi, Stefano; Kroon, Paul A.; Carrieri, Barbara; Cherubini, Antonio; Riso, Patrizia; Guglielmetti, Simone; Andrés Lacueva, Ma. Cristina (2023-01-24)

    A polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. ...