A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21). 

    Pérez Martí, Albert; Garcia-Guasch, Maite; Tresserra i Rimbau, Anna; Carrilho do Rosário, Alexandra; Estruch Riba, Ramon; Salas Salvadó, Jordi; Martínez-González, Miguel Ángel, 1957-; Lamuela Raventós, Rosa Ma.; Marrero González, Pedro F.; Haro Bautista, Diego; Relat Pardo, Joana (2020-06-11)

    Scope: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low ...

    Changes in white adipose tissue metabolism induced by resveratrol in rats. 

    Alberdi, Goiuri; Rodríguez, Víctor Manuel; Miranda, Jonatan; Mascarulla, María T.; Arias, Noemí; Andrés Lacueva, Ma. Cristina; Portillo, María Puy (2015-12-22)

    BACKGROUND: A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the ...

    Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability 

    Sabater Martínez, David; Arriarán, Sofía; Romero Romero, María del Mar; Agnelli, Silvia; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946- (2014-03-25)

    White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose ...

    Effect of cafeteria diet feeding on soleus intramyocellular lipid of Wistar rats 

    Cabot Majem, Cristina; Pouillot, Karl; Roy, Stéphanie; Romero Romero, María del Mar; Vilà Pont, Ruth; Grasa Martínez, Maria del Mar; Esteve Ràfols, Montserrat; Fernández López, José Antonio; Alemany, Marià, 1946-; Remesar Betlloch, Xavier (2014-05-02)

    Background: The presence of lipid besides muscle fibres facilitates the energy supply for exercise, but it is also indicative of insulin resistance in the untrained. Muscle lipid is associated with increased dietary energy: ...

    Effects of sex and site on amino acid metabolism enzyme gene expression and activity in rat white adipose tissue 

    Arriarán, Sofía; Agnelli, Silvia; Remesar Betlloch, Xavier; Fernández López, José Antonio; Alemany, Marià, 1946- (2016-02-29)

    Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/66872

    Evidences of basal lactate production in the main white adipose tissue sites of rats. Effects of sex and a cafeteria diet.  

    Arriarán, Sofía; Agnelli, Silvia; Sabater Martínez, David; Remesar Betlloch, Xavier; Fernández López, José Antonio; Alemany, Marià, 1946- (2015-05-13)

    Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric ...

    FGF21 mediates the lipid metabolism response to amino acid starvation 

    Sousa Coelho, Ana Luisa de; Relat Pardo, Joana; Hondares, E.; Pérez Martí, Albert; Ribas Aulinas, Francesc; Villarroya i Gombau, Francesc; Marrero González, Pedro F.; Haro Bautista, Diego (2020-05-25)

    Abstract Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fi broblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced ...

    Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges. 

    Martínez Garza, Úrsula; Torres-Oteros, Daniel; Yarritu-Gallego, Alex; Marrero González, Pedro F.; Haro Bautista, Diego; Relat Pardo, Joana (2020-05-27)

    The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate metabolism. FGF21 response is essential ...

    Glycerol production from glucose and fructose by 3T3L1 cells: a mechanism of adipocyte defense from excess substrate.  

    Romero Romero, María del Mar; Sabater Martínez, David; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946- (2015-10-13)

    Cultured adipocytes (3T3-L1) produce large amounts of 3C fragments; largely lactate, depending on medium glucose levels. Increased glycolysis has been observed also in vivo in different sites of rat white adipose tissue. ...

    Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile 

    Mera Nanín, Paula; Mir Bonnín, Joan Francesc; Fabriàs Domingo, Gemma; Casas Brugulat, Josefina; Costa, Ana S. H.; Malandrino, Maria Ida; Fernández López, José Antonio; Remesar Betlloch, Xavier; Gao, Su; Chohnan, Shigeru; Rodríguez-Peña, Maria Sol; Petry, Harald; Asins Muñoz, Guillermina; García Hegardt, Fausto; Herrero Rodríguez, Laura; Serra i Cucurull, Dolors (2014-09-17)

    Lipid metabolism in the ventromedial hypothalamus (VMH) has emerged as a crucial pathway in the regulation of feeding and energy homeostasis. Carnitine palmitoyltransferase (CPT) 1A is the rate-limiting enzyme in mitochondrial ...

    Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome 

    Castro-Barquero, Sara; Casas Rodríguez, Rosa M.; Rimm, Eric B.; Tresserra i Rimbau, Anna; Romaguera, Dora; Martínez Hernández, José Alfredo; Salas Salvadó, Jordi; Martínez-González, Miguel Ángel, 1957-; Vidal Cortada, Josep; Ruiz Canela, Miguel; Konieczna, Jadwiga; Sacanella, Emilio; García Gavilán, Jesús; Fitó Colomer, Montserrat; García Arellano, Ana; Estruch Riba, Ramon (2023-12-12)

    Scope: Excessive visceral adipose tissue (VAT) is associated with higher secretion of pro-inflammatory molecules, contributing to systemic inflammation and obesity-related metabolic disturbances. Methods & results: This ...

    Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice 

    Sandoval, Viviana; Femenias, Antoni; Martínez Garza, Úrsula; Sanz Lamora, Héctor; Castagnini, Juan Manuel; Quifer Rada, Paola; Lamuela Raventós, Rosa Ma.; Marrero González, Pedro F.; Haro Bautista, Diego; Relat Pardo, Joana (2020-05-07)

    Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on ...

    Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss. 

    Tulipani, Sara; Griffin, Jules; Palau Rodríguez, Magalí; Mora Cubillos, Lyda Ximena; Bernal López, M. Rosa; Tinahones, Francisco J.; Corkey, Barbara E.; Andrés Lacueva, Ma. Cristina (2020-05-26)

    Despite evidence to support their utility, lifestyle-based strategies for weight loss and treatment of obesity (i.e., based on diet and physical activity) have met so far with little success in the long term in terms of ...

    Pharmacological strategies for targeting BAT thermogenesis 

    Whittle, Andrew J.; Relat Pardo, Joana; Vidal-Puig, Antonio (2021-07-08)

    Modern imaging techniques have confirmed the presence of thermogenically active brown adipose tissue (BAT) in adult humans, leading to suggestions that it could be stimulated to treat obesity and its associated morbidities. ...

    Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue 

    Salas Mani, Anna; Noé Mata, Verónica; Ciudad i Gómez, Carlos Julián; Romero Romero, María del Mar; Remesar Betlloch, Xavier; Esteve Ràfols, Montserrat (2009-03-20)

    Background: Short-term OE (oleoyl-estrone) treatment causes significant decreases in rat weight mainly due to adipose tissue loss. The aim of this work was to determine if OE treatment affects the expression of genes that ...

    Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

    Whittle, Andrew J.; Jiang, Meizi; Peirce, Vivian; Relat Pardo, Joana; Virtue, Sam; Ebinuma, Hiroyuki; Fukamachi, Isamu; Yamaguchi, Takashi; Takahashi, Mao; Murano, Takeyoshi; Tatsuno, Ichiro; Takeuchi, Masahiro; Nakaseko, Chiaki; Jin, Wenlong; Jin, Zhehu; Campbell, Mark; Schneider, Wolfgang J; Vidal-Puig, Antonio; Bujo, Hideaki (2020-06-23)

    Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...

    Steroid hormones interrelationships in the metabolic syndrome: an introduction to the ponderostat hypothesis 

    Alemany, Marià, 1946- (2014-05-05)

    Sexual dimorphism in the metabolic syndrome. The clairvoyant early implication of sex hormones in the characterization of the metabolic syndrome (MS) was detected early, and in accordance with the well-known sex-related ...

    The urea cycle of rat white adipose tissue 

    Arriarán, Sofía; Agnelli, Silvia; Remesar Betlloch, Xavier; Fernández López, José Antonio; Alemany, Marià, 1946- (2016-02-22)

    White adipose tissue (WAT) contains a powerful metabolic machinery related to energy metabolism and partition. The adaptive, regulatory, size and structural variety of WAT agrees with this control role. However, its nitrogen ...

    Trajectories of adherence to an obesogenic dietary pattern and changes in diet quality, food intake, and adiposity during adolescence 

    Martínez Gómez, Jesús; Bodega, Patricia; Santos-Beneit, Gloria; de Cos-Gandoy, Amaya; Beneito-Durá, María; Miguel, Mercedes de; Tresserra i Rimbau, Anna; Ruíz León, Ana María; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.; Moreno, Luis A.; Fernández Alvira, Juan Miguel; Fernandez-Jimenez, Rodrigo (2025-10-09)

    Background and Aims</h3><p>Contemporary longitudinal data on dietary patterns (DP) during adolescence are scarce. This study aimed to identify trajectories of adherence to an obesogenic DP and changes in diet quality (DQ), ...

    Treatment of pregnant rats with oleoyl-estrone slows down pup fat deposition after weaning 

    García Peláez, Beatriz; Vilà Pont, Ruth; Remesar Betlloch, Xavier (2009-03-25)

    BACKGROUND: In rats, oral oleoyl-estrone (OE) decreases food intake and body lipid content. The aim of this study was to determine whether OE treatment affects the energy metabolism of pregnant rats and eventually, of their ...