Institut de Nanociència i Nanotecnologia (IN2UB): Recent submissions
Now showing items 141-160 of 375
Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has ...
Effects of ITO based back contacts on Cu(In,Ga)Se2 thin films, solar cells, and mini-modules relevant for semi-transparent building integrated photovoltaics
This study presents the results of the development of semi-transparent Cu(In,Ga)Se2 (CIGSe) mini-modules for the application in building integrated photovoltaics (BIPV). Applying in-situ X-ray diffraction in real-time ...
Chondroitin Sulfate for cartilage regeneration, administered topically using a nanostructured formulation
In the pharmaceutical sector, solid lipid nanoparticles (SLN) are vital for drug delivery incorporating a lipid core. Chondroitin sulfate (CHON) is crucial for cartilage health. It is often used in osteoarthritis (OA) ...
Novel strategies enhancing endodontic disinfection: antibacterial biodegradable calcium hydroxide nanoparticles in an ex vivo model
<span style="color:rgb( 33 , 33 , 33 )">Due to the high failure rates associated to endodontic disinfection, this study aimed to investigate the antibacterial properties of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ...
Iron oxide nanoparticles for magnetically guided and magnetically responsive drug delivery
In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a ...
Human skin permeation studies with PPARγ agonist to improve its permeability and efficacy in inflammatory processes
Rosacea is the most common inflammatory skin disease. It is characterized by erythema, inflammatory papules and pustules, visible blood vessels, and telangiectasia. The current treatment has limitations and unsatisfactory ...
Memantine loaded PEGylated biodegradable nanoparticles for the treatment of glaucoma
Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC) loss. Increasing reports of similarities in glaucoma and other neurodegenerative conditions have led to speculation that ...
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization
Background: Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to be fully efective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution ...
PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen in vitro, ex vivo and in vivo characterization
Dexibuprofen-loaded PEGylated PLGA nanospheres have been developed to improve the biopharmaceuti-cal profile of the anti-inflammatory drug for ocular administration. Dexibuprofen is the active enantiomerof ibuprofen and ...
Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery
A cationic bis‐imidazolium‐based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the ...
Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale
Suspended planar-array (SPA) chips embody millions of individual miniaturized arrays to work in extremely small volumes. Here, the basis of a robust methodology for the fabrication of SPA silicon chips with on-demand ...
In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds
Nowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid ...
Combining three-dimensionality and CaP glass-PLA composites: Towards an efficient vascularization in bone tissue healing
Bone regeneration often fails due to implants/grafts lacking vascular supply, causing necrotic tissue and poor integration. Microsurgical techniques are used to overcome this issue, allowing the graft to anastomose. These ...
Engineering Cell-Derived Matrices: From 3D Models to Advanced Personalized Therapies
Regenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ...
An immunoPEGliposome for targeted antimalarial combination therapy at the nanoscale
Combination therapies, where two drugs acting through different mechanisms are administered simultaneously, are one of the most efficient approaches currently used to treat malaria infections. However, the different ...
Custom incorporation of DMD-based photolithography and photopatterning techniques in soft condensed matter research
Research with soft materials, that is, polymeric gels, colloidal suspensions, liquid crystals, and most biomaterials often involves the need for microfabrication of confinement channels, cells, and lab-on-a-chip devices. ...
Wound healing-promoting effects stimulated by extracellular calcium and calcium-releasing nanoparticles on dermal fibroblasts
Extracellular calcium has been proved to influence the healing process of injuries and could be used as a novel therapy for skin wound healing. However, a better understanding of its effect, together with a system to obtain ...
Cholesterol effect on the specific capacitance of submicrometric DOPC bilayer patches measured by in-liquid scanning dielectric microscopy
The specific capacitance of biological membranes is a key physical parameter in bioelectricity that also provides valuable physicochemical information on composition, phase, or hydration properties. Cholesterol is known ...
Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial stragegy
One of the most important factors behind resistance evolution in malaria is the failure to deliver sufficiently high amounts of drugs to early stages of Plasmodium-infected red blood cells (pRBCs). Despite having been ...
