Institut de Bioenginyeria de Catalunya (IBEC): Recent submissions
Now showing items 1-20 of 641
FleQ-Dependent regulation of the ribonucleotide reductase repressor NrdR in Pseudomonas aeruginosa during biofilm growth and infection
Ribonucleotide reductases (RNRs) are essential enzymes that catalyze the conversion of ribonucleotides to deoxyribonucleotides (dNTPs), a critical step in DNA synthesis and repair. While all organisms encode for at least ...
Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial hits
4,9-diaminoacridines with reported antiplasmodial activity were coupled to different trans-cinnamic acids, delivering a new series of conjugates inspired by the covalent bitherapy concept. The new compounds were more potent ...
Multicomponent nasal spray delivered via penetration-enhancer containing vesicles (PEVs) for antioxidant and antibacterial protection
In this study, a nasal spray was formulated and tested co-loading grape seed extract, thymol, and camphor in penetration enhancer containing vesicles (PEVs) tailored to synergistically protect the nasal mucosa against ...
In vitro and in vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats
In this study the wound healing efficacy of new self-assembling curcumin loaded nanohyaluronan-glycerosomes has been tested in healthy and diabetic rats. Curcumin was loaded in nanohyaluronan-liposomes and -glycerosomes, ...
The minimal chemotactic cell
The movement of cells and microorganisms in response to chemical gradients (chemotaxis) has played an essential role in the evolution of many biological processes. Cellular navigation works via the holistic assembly of ...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
The blood‒brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially harmful substances while regulating the transport of essential molecules. Its ...
Thermoplasmonic Polymersome Membranes by In Situ Synthesis
Thermoplasmonic nanoparticles, known for releasing heat upon illumination, find diverse applications in catalysis, optics, and biomedicine. Incorporating plasmonic metals within organic vesicle membranes can lead to the ...
Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
3D printing has emerged as a transformative technology in several manufacturing processes, being of particular interest in biomedical research for allowing the creation of 3D structures that mimic native tissues. The process ...
Convolutional Neural Networks for Apnea Detection from Smartphone Audio Signals: Effect of Window Size
Although sleep apnea is one of the most prevalent sleep disorders, most patients remain undiagnosed and untreated. The gold standard for sleep apnea diagnosis, polysomnography, has important limitations such as its high ...
Enzymatic Reactions Observed with Zero- and Low-Field Nuclear Magnetic Resonance
We demonstrate that enzyme-catalyzed reactions can be observed in zero- and low-field NMR experiments by combining recent advances in parahydrogen-based hyperpolarization methods with state-of-the-art magnetometry. ...
Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo
To interrogate neural circuits and crack their codes, in vivo brain activity imaging must be combined with spatiotemporally precise stimulation in three dimensions using genetic or pharmacological specificity. This challenge ...
Engineered muscle tissues for disease modeling and drug screening applications
Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, ...
Stiffness-dependent active wetting enables optimal collective cell durotaxis
The directed migration of cellular clusters enables morphogenesis, wound healing and collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular clusters in a process called collective ...
Flexible sensors for biomedical technology
Flexible sensing devices have gained a great deal of attention among the scientific community in recent years. The application of flexible sensors spans over several fields, including medicine, industrial automation, ...
Enzyme-powered micro- and nano-motors: key parameters for an application-oriented design
Nature has inspired the creation of artificial micro- and nanomotors that self-propel converting chemical energy into mechanical action. These tiny machines have appeared as promising biomedical tools for treatment and ...
A Multiscale Study of Phosphorylcholine Driven Cellular Phenotypic Targeting
AbstractPhenotypic targeting requires the ability of the drug delivery system to discriminate over cell populations expressing a particular receptor combination. Such selectivity control can be achieved using multiplexed ...
