Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis 

Pulido Salgado, Marta; Vidal Taboada, José Manuel; García-Díaz Barriga, Gerardo; Serratosa i Serdà, Joan; Valente, Tony; Castillo, Paola; Matalonga, Jonathan; Straccia, Marco; Canals i Coll, Josep M.; Valledor Fernández, Annabel; Solà i Subirana, Carme; Saura Martí, Josep (Publication date: 2017-03-27)

Background CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for C/EBPβ show protection against excitotoxic ...

ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution 

Royo, Romina; Magnano, Laura; Delgado, Julio; Ruiz Gil, Sara; Gelpi Buchaca, Josep Lluís; Heyn, Holger; Taylor, Malcom A.; Stankovic, Tatjana; Puente, Xose S.; Nadeu Prat, Ferran; Campo Güerri, Elias (Publication date: 2023-07-05)

Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, ...

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape 

Rodríguez García, Alba; Palazón, Asis; Noguera Ortega, Estela; Powell, Daniel J.; Guedán Carrió, Sònia (Publication date: 2020-07-31)

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy ...

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia 

Ferreira, Pedro G.; Jares Gerboles, Pedro; Rico, Daniel; Gómez López, Gonzalo; Martínez Trillos, Alejandra; Villamor i Casas, Neus; Ecker, Simone; González-Pérez, Abel; Knowles, David G.; Monlong, Jean; Johnson, Rory; Quesada, Victor; Djebali, Sarah; Papasaikas, Panagiotis; López-Guerra, Mónica; Colomer Pujol, Dolors; Royo Moreno, Cristina; Cazorla, Maite; Pinyol, Magda; Clot Razquin, Guillem; Aymerich Gregorio, Marta; Rozman, María; Kulis, Marta; Tamborero Noguera, David; Gouin, Anaïs; Blanc, Julie; Gut, Marta; Gut, Ivo G.; Puente, Xose S.; Pisano, David G.; Martín-Subero, José Ignacio; López Bigas, Núria; López Guillermo, Armando; Valencia, Alfonso; López-Otin, Carlos; Campo Güerri, Elias; Guigó Serra, Roderic (Publication date: 2017-03-20)

Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying ...

Trends in revascularization therapies for patients with acute stroke with large infarcts: A population-based study 

Doncel Moriano, Antonio; Rodríguez Vázquez, Alejandro; Rosa, Irene; Rudilosso, Salvatore; Serrano Clerencia, Mònica; Renú, Arturo; Cabero Arnold, Andrea; Blasco, Jordi; Amaro, Sergio; Llull, Laura; Molina, Carlos A.; Cardona Portela, Pere; Camps Renom, Pol; Millán, Mónica; Figueras Aguirre, Georgina; Rodríguez Campello, Ana; Silva, Yolanda; Purroy, Francisco; Salvat, Mercè; Vargas, Martha; Urra, Xabier; Chamorro Sánchez, Ángel (Publication date: 2025-12-23)

Background Evidence from randomized clinical trials shows that mechanical thrombectomy (MT) enhances functional outcomes in patients with large core ischemic stroke. Objective To evaluate trends in the use of revascularization ...

Exogenous Liposomal ceramide-c6 ammeliorates lipidomic profile, energy homeostasis and anti-oxidant systems in NASH 

Zanieri, Francesca; Levi, Ana; Montefusco, David; Longato, Lisa; De Chiara, Francesco; Frenguelli, Luca; Omenetti, Sara; Andreola, Fausto; Luong, Tu Vinh; Massey, Veronica; Caballeria Rovira, Joan; Fondevila Campo, Constantino; Shanmugavelandy, Sriram S.; Fox, Todd; Mazza, Giuseppe; Argemi, Josep Maria; Bataller Alberola, Ramón; Cowart, Lauren Ashley; Kester, Mark; Pinzani, Massimo; Rombouts, Krista (Publication date: 2021-03-10)

In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism ...

Pulmonary vascular disease in chronic lung diseases: cause or comorbidity? 

Blanco Vich, Isabel; Torres Castro , Rodrigo; Barberà i Mir, Joan Albert (Publication date: 2024-12-03)

To provide timely and relevant insights into the complex relationship between pulmonary vascular disease (PVD) and chronic lung disease (CLD), focusing on the causative and consequential dynamics between these conditions. ...

Role and Utility of Mixed Reality Technology in Laparoscopic Partial Nephrectomy: Outcomes of a Prospective RCT Using an Indigenously Developed Software 

Gadzhiev, Nariman; Semeniakin, Igor; Morshnev, Aleksandr; Alcaraz Asensio, Antonio; Gauhar, Vineet; Okhunov, Zhamshid (Publication date: 2023-08-02)

Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers 

Moncunill, Gemma; Aguilar, Ruth; Ribes, Marta; Ortega, Natalia; Rubio, Rocío; Salmerón, Gemma; Molina, María José; Vidal, Marta; Barrios, Diana; Mitchell, Robert A.; Jiménez, Alfons; Castellana, Cristina; Hernández-Luis, Pablo; Rodó, Pau; Méndez, Susana; Llupià García, Anna; Puyol, Laura; Rodrigo Melero, Natalia; Carolis, Carlo; Mayor Aparicio, Alfredo Gabriel; Izquierdo, Luis; Varela, Pilar; Trilla Garcia, Antonio De Padua; Vilella, Anna; Barroso, Sonia; Angulo Aguado, Ana; Engel Rocamora, Pablo; Tortajada, Marta; Garcia-Basteiro, Alberto L.; Dobaño, Carlota, 1969- (Publication date: 2026-01-19)

Background: Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to ...

Eosinophilic Infiltration of the Sino-Atrial Node in Sudden Cardiac Death Caused by Long QT Syndrome 

Grassi, Simone; Campuzano Larrea, Oscar; Coll, Mònica; Cazzato, Francesca; Iglesias, Anna; Ausania, Francesco; Scarnicci, Francesca; Sarquella Brugada, Georgia; Brugada Terradellas, Josep, 1958-; Arena, Vicenzo; Oliva, Antonio; Brugada, Ramon (Publication date: 2023-06-21)

Sudden death is defined as the unexpected death of a healthy person that occurs within the first hour of the onset of symptoms or within 24 h of the victim being last seen alive. In some of these cases, rare deleterious ...

Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers 

Haddad Tovolli, Roberta; Morari, Joseane; Barbizan, Roberta; Bóbbo, Vanessa; Carraro, Rodrigo; Solon, Carina; Dragano, Nathalia; Torsoni, Márcio; Araujo, Eliana; Velloso, Licio (Publication date: 2023-11-15)

Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by ...

Eating disorders during gestation: Implications for mother's health, fetal outcomes, and epigenetic changes 

Sebastiani, Giorgia; Andreu Fernández, Vicente; Herranz Barbero, Ana; Aldecoa, Victoria; Miracle, Xavier; Meler Barrabés, Eva; Balada Ibáñez, Arantxa; Astals Vizcaíno, Marta; Ferrero Martínez, Silvia; Gómez Roig, Ma. Dolores; García Algar, Óscar (Publication date: 2021-04-28)

Introduction: Eating disorders (EDs) have increased globally in women of childbearing age, related to the concern for body shape promoted in industrialized countries. Pregnancy may exacerbate a previous ED or conversely ...

Effect of immunosuppression in miRNAs from extracellular vesicles of colorectal cancer and their influence on the pre-metastatic niche 

Ramírez Bajo, María José; Revuelta, Ignacio; Tubita, Valeria; Seguí Barber, Joan; Lozano, Juan José; Bañón Maneus, Elisenda; Rovira, Jordi; Cucchiari, David; Moya Rull, Daniel; Oppenheimer Salinas, Federico; Del Portillo, Hernando A.; Campistol Plana, Josep M.; Diekmann, Fritz (Publication date: 2025-12-05)

Colorectal cancer (CRC) occurs with more aggressiveness in kidney transplant recipients compared to the general population. Immunosuppressive therapy plays a crucial role in the development of post-transplant malignancy. ...

Proresolving lipid mediators and liver disease. 

Clària i Enrich, Joan; Flores Costa, Roger; Duran Güell, Marta; López Vicario, Cristina (Publication date: 2022-03-31)

Inflammation is a characteristic feature of virtually all acute and chronic liver diseases. It intersects different liver pathologies from the early stages of liver injury, when the inflammatory burden is mild-to-moderate, ...

Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene 

Ortega, Mireia; Toma, Ilario de; Fernández Blanco, Álvaro; Calderón, Anna; Barahona, Lucía; Trullàs i Oliva, Ramon; Sabidó, Eduard; Dierssen, Mara (Publication date: 2023-08-02)

DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also been implicated ...

Diagnostic Yield of Exome Sequencing in Fetuses With Multisystem Malformations: Systematic Review and Meta-analysis 

Pauta, Montse; Martínez Portilla, Raigam J.; Borrell, Antoni (Publication date: 2024-10-25)

Objective: To determine the diagnostic yield of exome sequencing (ES) above that of chromosomal microarray analysis (CMA) or karyotyping in fetuses with multisystem structural anomalies (at least two major anomalies in ...

Immunotherapy in Advanced Prostate Cancer: Current Knowledge and Future Directions 

López Campos, Fernando; Gajate, Pablo; Romero Laorden, Nuria; Zafra Martín, Juan; Juan, Manel; Hernando Polo, Susana; Conde Moreno, Antonio; Couñago, Felipe (Publication date: 2023-09-21)

The advent of immunotherapy has revolutionized cancer treatment. Unfortunately, this has not been the case for metastatic castration-resistant prostate cancer (mCRPC), likely due to the heterogeneous and immune-suppressive ...

TRPV2: A Key Player in Myelination Disorders of the Central Nervous System 

Enrich Bengoa, Jennifer; Manich Raventós, Gemma; Valente, Tony; Sanchez Molina, Paula; Almolda, Beatriz; Solà i Subirana, Carme; Saura Martí, Josep; González, Berta; Castellano, Bernardo; Perálvarez Marín, Alex (Publication date: 2022-05-17)

Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, ...

Melanoma-specific survival is worse in the elderly: a multicentric cohort study 

Segura, Sonia; Podlipnik, Sebastian; Boada, Aram; Martí, Rosa M.; Sabat, Mireia; Yélamos, Oriol; Zarzoso Muñoz, Inés; Azón Masoliver, Antoni; López Castillo, Daniel; Solà, Joaquim; Baliu Piqué, Carola; Galvany Rossell, Loida; Pasquali, Paola; Just Sarobé, Miquel; Duran, Xavier; Carrera Álvarez, Cristina; Richarz, Nina A.; Pujol, Ramon M.; Malvehy, J. (Josep); Network Melanoma Ctr Catalonia; Puig i Sardà, Susana (Publication date: 2024-03-25)

We aimed to characterise cutaneous melanoma in the elderly and determine its association with poorer prognosis. We studied a prospective cohort of the melanoma population in Catalonia between 2012 and 2016. We compared ...

Bepirovirsen - a new therapy for chronic Hepatitis B Infection 

Lens García, Sabela (Publication date: 2023-12-11)