IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer: Recent submissions
Now showing items 141-160 of 3164
Assessment of in vivo versus in vitro biofilm formation of clinical methicillin-resistant Staphylococcus aureus isolates from endotracheal tubes
Our aim was to demonstrate that biofilm formation in a clinical strain of methicillin-resistant Staphylococcus aureus (MRSA) can be enhanced by environment exposure in an endotracheal tube (ETT) and to determine how it is ...
High-Throughput Task to Study Memory Recall During Spatial Navigation in Rodents
© Copyright © 2020 Morales, Tomàs, Dalmau, de la Rocha and Jercog. Spatial navigation is one of the most frequently used behavioral paradigms to study memory formation in rodents. Commonly used tasks to study memory are ...
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells ...
Commensal-Specific CD4(+) Cells From Patients With Crohn's Disease Have a T-Helper 17 Inflammatory Profile
BACKGROUND & AIMS: Crohn's disease (CD) has been associated with an altered immune response to commensal microbiota, mostly based on increased seroreactivity to microbial proteins. Although T cells are believed to contribute ...
Alterations in the abundance of protamine proteoforms related to sperm chromatin packaging, obesity, and age in normozoospermic men
Protamines are considered among the most relevant sperm proteins because of their functional implications on paternal genome packaging and protection. Although the proteomic evaluation of protamines is technically challenging, ...
Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
Background To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of ...
Genetic variation associated with cardiovascular risk in autoimmune diseases
Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. ...
Development and validation of a multivariable prediction model of spontaneous preterm delivery and microbial invasion of the amniotic cavity in women with preterm labor
BACKGROUND: Early spontaneous preterm delivery is often associ- ated with microbial invasion of the amniotic cavity and/or intraamniotic inflammation. OBJECTIVE: The objective of the study was to develop and validate ...
Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients
Background: Marfan syndrome (MFS) is a genetic disease, characterized by thoracic aortic aneurysm (TAA), which treatment is to date purely surgical. Understanding of novel molecular targets is mandatory to unveil e ective ...
Respiratory viruses: their importance and lessons learned from COVID-19
Respiratory virus infection can cause severe illnesses capable of inducing acute respiratory failure that can progress rapidly to acute respiratory distress syndrome (ARDS). ARDS is related to poor outcomes, especially in ...
Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies
The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study ...
Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
BACKGROUND: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still ...
Alteracions del DNA mitocondrial implicades en patologia Humana
La majoria del gens humans es localitzen al nucli de la cèl·lula i s'hereten d'ambdós progenitors. N'existeixen d'altres que es troben al citoplasma, concretament a l'interior dels mitocondris, i són d'origen exclusivament ...
Prevalence, diagnostic accuracy, and healthcare utilization patterns in patients with COPD in primary healthcare: a population-based study
Underdiagnosis and overdiagnosis commonly occur in Chronic Obstructive Pulmonary Disease (COPD) patients. We assessed diagnostic accuracy, clinical characteristics, healthcare utilization, and care plan registration for ...
The role of peroral cholangioscopy in liver transplant recipients: A prospective, international series
Background Biliary strictures are a common complication of living and deceased donor liver transplantation. Peroral cholangioscopy (POCS) with POCS-guided biliary tract biopsies may improve diagnostic accuracy compared ...
Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities
Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification ...
Blocking Placental Class G Immunoglobulin Transfer Prevents NMDA Receptor Antibody Effects in Newborn Mice
To determine in a mouse model whether neonatal Fc receptor (FcRn) blockade prevents the placental transfer of class G immunoglobulin (IgG) derived from patients with anti-NMDA receptor (NMDAR) encephalitis and their ...
Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
A model of K-Ras-initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma. In hypoxic, Tgf-β1-rich interiors of adenomas, we show that adenoma cells divide asymmetrically to produce ...
