Aggressive Course in Encephalitis With Opsoclonus, Ataxia, Chorea, and Seizures. The First Pediatric Case of γ-Aminobutyric Acid Type B Receptor Autoimmunity 

Kruer, Michael C.; Höftberger, Romana; Lim, Kit Yeng; Coryell, Jason C.; Svoboda, Melissa D.; Woltjer, Randall L.; Dalmau Obrador, Josep (Publication date: 2018-02-07)

IMPORTANCE: Autoantibodies to the γ-aminobutyric acid type B (GABAB) receptor have recently been identified as a cause of autoimmune encephalitis. Most patients with GABAB encephalitis have presented with limbic encephalitis. ...

Exploring risk and resilient profiles for functional impairment and baseline predictors in a 2-year follow-up first-episode psychosis cohort using latent class growth analysis 

Salagre Muñoz, Estela; Grande i Fullana, Iria; Solé Cabezuelo, Brisa; Mezquida Mateos, Gisela; Cuesta, Manuel J.; Díaz Caneja, Covadonga M.; Amoretti Guadall, Silvia; Lobo, Antonio; González-Pinto, Ana; Moreno, Carmen (Moreno Koch); Pina Camacho, Laura; Corripio, Iluminada; Baeza, Inmaculada, 1970-; Bergé, Daniel; Verdolini, Norma; Carvalho, André F.; Vieta i Pascual, Eduard, 1963-; Bernardo Arroyo, Miquel; PEPs Group (Publication date: 2021-02-18)

Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in ...

Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer. 

Garcia Recio, Susana; Fuster Orellana, Gemma; Fernandez-Nogueira, Patricia; Pastor Arroyo, Eva M.; Yeong Park, So; Mayordomo, Cristina; Ametller, Elisabet; Mancino, Mario; Gonzalez-Farre, Xavier; Russnes, Hage G.; Engel Rocamora, Pablo; Costamagna, Domiziana; Fernandez, Pedro L.; Gascón, Pere; Almendro Navarro, Vanessa (Publication date: 2018-02-26)

ERBB receptor transmodulation by heterologous G-protein-coupled receptors (GPCR) generates functional diversity in signal transduction. Tachykinins are neuropeptides and proinflammatory cytokines that promote cell survival ...

MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence 

Morais‑Almeida, M.; Antó i Boqué, Josep Maria; Mullol i Miret, Joaquim; Valero, Antonio; MASK study group (Publication date: 2020-03-03)

Health, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not ...

Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis 

Mullol i Miret, Joaquim; Izquierdo, Iñaki; Okubo, Kimihiro; Canonica, Giorgio Walter; Bousquet, Jean; Valero, Antonio (Publication date: 2020-03-03)

Background: Diferent clinical trials showed the superior efcacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically ...

Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients. 

García-López, Mireia; Lens García, Sabela; Pallett, Laura J.; Testoni, Barbara; Rodríguez Tajes, Sergio; Mariño Méndez, Zoe; Bartrés, Concepció; García Pras, Ester; Leonel, Thais; Perpiñán, Elena; Lozano, Juan José; Rodríguez-Frías, Francisco; Koutsoudakis, George; Zoulim, Fabien; Maini, Mala K; Forns, Xavier; Pérez del Pulgar Gallart, Sofía (Publication date: 2024-09-03)

Background & aims: Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this ...

Clinical significance and applications of oscillometry 

Kaminsky, David A.; Simpson, Shannon J.; Berger, Kenneth I.; Calverley, Peter M.; De Melo, Pedro L.; Dandurand, Ronald; Dellacà, Raffaele L.; Farah, Claude S.; Farré Ventura, Ramon; Hall, Graham L.; Ioan, Iulia; Irvin, Charles G.; Kaczka, David W.; King, Gregory G.; Kurosawa, Hajime; Lombardi, Enrico; Maksym, Geoffrey N.; Marchal, François; Oostveen, Ellie; Oppenheimer, Beno W.; Robinson, Paul D.; Van den Berge, Maarten; Thamrin, Cindy (Publication date: 2023-08-28)

Recently, 'Technical standards for respiratory oscillometry' was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, ...

Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy 

Garcia Pouton, Nicol; Ortiz-Maldonado Gibson, Valentín; Peyrony, Oliver; Chumbita, Mariana; Aiello, Tommaso Francesco; Monzó Gallo, Patricia; Lopera, Carlos; Puerta-Alcalde, Pedro; Magnano, Laura; Martínez Cibrian, Nuria; Pitart, Cristina; Juan, Manel; Delgado, Julio; Fernández de Larrea Rodríguez, Carlos José; Soriano Viladomiu, Alex; Urbano Ispizua, Álvaro; Garcia Vidal, Carolina (Publication date: 2024-01-24)

Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts 

Dobaño, Carlota, 1969-; Alonso, Selena; Vidal, Marta; Jiménez, Alfons; Rubio, Rocío; Santano, Rebeca; Barrios, Diana; Pons Tomàs, Gemma; Melé Casas, Maria; Hernández García, María; Girona Alarcón, Mònica; Puyol, Laura; Baro, Bàrbara; Millat Martínez, Pere; Ajanovic, Sara; Balanza Lombardia, Núria; Arias, Sara; Rodrigo Melero, Natalia; Carolis, Carlo; García Miquel, Aleix; Bonet Carné, Elisenda; Claverol, Joana; Cubells, Marta; Fortuny Guasch, Claudia; Fumadó, Victoria; Codina, Anna; Bassat Orellana, Quique; Muñoz Almagro, Carmen; Fernández de Sevilla Estrach, Mariona; Gratacós Solsona, Eduard; Izquierdo Lázaro, Luis; García García, Juan José; Aguilar, Ruth; Jordán García, Iolanda; Moncunill Piñas, Gemma (Publication date: 2022-06-20)

COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 to their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed to evaluate the ...

Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis. 

Callejas, Francisco de Borja; Martínez Antón, Ma. Asunción; Alobid, Isam; Fuentes Prado, Mireya; Cortijo, Julio; Picado Vallés, César; Roca i Ferrer, Jordi; Mullol i Miret, Joaquim (Publication date: 2018-05-07)

BACKGROUND: Primary human airway epithelial cells cultured in an air-liquid interface (ALI) develop a well-differentiated epithelium. However, neither characterization of mucociliar differentiation overtime nor the ...

Cost-accuracy and patient experience assessment of blood pressure monitoring methods to diagnose hypertension: A comparative effectiveness study 

González de Paz, Luis; Kostov, Bechim; Freixa, Xavier; Herranz, Carmen; Lagarda, Elena; Ortega, María; Pérez, Elisa; Porcar, Sílvia; Sánchez, Eva; Serrato, Montserrat; Vidiella, Íngrid; Sisó Almirall, Antoni (Publication date: 2024-03-25)

Studies of the diagnosis of hypertension have emphasized long-term cost-effectiveness analysis, but the patient experience and costs of blood pressure monitoring methods at the diagnosis stage remain unclear. We studied ...

Cognitive dysfunction in Huntington¿s disease: Humans, mouse models and molecular mechanisms 

Giralt Torroella, Albert; Saavedra, Ana; Alberch i Vié, Jordi, 1959-; Pérez Navarro, Esther (Publication date: 2022-02-17)

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder due to an expanded CAG/polyglutamine repeat in the coding region of the huntingtin (htt) gene that causes the preferential degeneration ...

Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset 

Chua, Winnie; Easter, Christina L.; Guasch i Casany, Eduard; Sitch, Alice; Casadei, Barabara; Crijns, Harry J.G.M.; Haase, Doreen; Hatem Stéphane; Kääb, Stefan; Mont Girbau, Lluís; Schotten, Ulrich; Sinner, Moritz F.; Hemming, Karla; Deeks, Jonathan J.; Kirchhof, Paulus; Fabritz, Larissa (Publication date: 2020-05-29)

Background: Atrial fibrillation (AF) is caused by different mechanisms but current treatment strategies do not target these mechanisms. Stratified therapy based on mechanistic drivers and biomarkers of AF have the potential ...

QT interval and short-term outcome in acute heart failure 

Miró i Andreu, Òscar; Aguiló, Oriol; Trullàs, Joan Carles; Gil Espinosa, Victor; Espinosa, Begoña; Jacob, Javier; Herrero Puente, Pablo; Tost, Josep; López-Grima, María Luisa; Comas, Pere; Bibiano, Carlos; Llauger, Lluís; Martín Mojarro, Enrique; López Díez, María Pilar; Nuñez, Julio; Rafique, Zubaid; Keene, Kelly R.; Peacock, Frank; Lopez-Ayala, Pedro; Mueller, Christian; Montero Pérez-Barquero, Manuel; Mont Girbau, Lluís; Llorens Soriano, Pere; ICA-SEMES research investigators (Publication date: 2025-04-30)

Objective: To investigate the association of corrected QT (QTc) interval duration and short-term outcomes in patients with acute heart failure (AHF). Methods: We analyzed AHF patients enrolled in 11 Spanish emergency ...

Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes 

Palacio, Montse; Kühnert, Maritta; Berger, Richard; Larios, Cindy L.; Marcellin, Louis (Publication date: 2018-03-20)

BACKGROUND: Premature rupture of the membranes (PROM) is most commonly diagnosed using physical examination; however, accurate decision making in ambiguous cases is a major challenge in current obstetric practice. As this ...

Non-invasive candidate protein signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response 

Richards, Shola M.; Guo, Fang; Zou, Heng; Nigsch, Florian; Baiges Aznar, Anna; Pachori, Alok; Zhang, Yiming; Lens García, Sabela; Pitts, Rebecca; Finkel, Nancy; Loureiro, Joseph; Mongeon, Dale; Ma, Shenglin; Watkins, Mollie; Polus, Florine; Albillos, Agustín; Tellez, Luis; Martinez González, Javier; Bañares, Rafael; Turon, Fanny; Ferrusquía Acosta, José; Pérez Campuzano, Valeria; Magaz Martínez, Marta; Forns, Xavier; Badman, Michael; Sailer, Andreas W.; Ukomadu, Chinweike; Hernández Gea, Virginia; García Pagán, Juan Carlos (Publication date: 2025-05-12)

Background and aims: A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing the severity of portal hypertension and the effectiveness of intervention treatments. This study aimed ...

Cell-Free DNA for Genomic Analysis in Primary Mediastinal Large B-Cell Lymphoma 

Rivas Delgado, Alfredo; Nadeu Prat, Ferran; Andrade Campos Marcio; López González, Cristina; Enjuanes, Anna; Mozas, Pablo; Frigola, Gerard; Colomo Saperas, Lluís; Sánchez González, Blanca; Villamor i Casas, Neus; Beà Bobet, Sílvia M.; Campo Güerri, Elias; Salar, Antonio; Giné Soca, Eva; López Guillermo, Armando; Bellosillo Paricio, Beatriz (Publication date: 2023-07-04)

High-throughput sequencing of cell-free DNA (cfDNA) has emerged as a promising noninvasive approach in lymphomas, being particularly useful when a biopsy specimen is not available for molecular analysis, as it frequently ...

Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona 

Sisó Almirall, Antoni; Kostov, Belchin; Mas Heredia, Minerva; Vilanova Rotllan, Sergi; Sequeira Aymar, Ethel; Sans Corrales, Mireia; Sant Arderiu, Elisenda; Cayuelas Redondo, Laia; Martinez Pérez, Angela; Garcia Plana, Noemi; Anguita Guimet, August; Benavent Àreu, Jaume (Publication date: 2022-03-17)

Background In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community. Aim To determine clinical factors ...

The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas 

Sanchez Tillo, E.; Pedrosa, Leire; Vila, I.; Chen, Yao; Gyorffy, B.; Sánchez Moral, L.; Siles Mena, Laura; Lozano Salvatella, Juan José; Esteve Codina, A.; Darling, Douglas S.; Cuatrecasas Freixas, Miriam; Castells Garangou, Antoni; Maurel Santasusana, Joan; Postigo, Antonio (Publication date: 2024-03-13)

Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse ...

The influence of CYP enzymes and ABCB1 on treatment outcomes in schizophrenia: association of CYP1A2 activity with adverse effects 

Cendrós, Marc; Arranz, María Jesús; Torra, Mercè; Penadés Rubio, Rafael; Gonzalez-Rodriguez A; Brunet i Serra, Mercè; Pérez Blanco, Josefina; Ibáñez Lladó, Laura; Serra, Àlex; Catalán, Rosa (Publication date: 2021-02-15)

Aim: Genetic variants on metabolic and transport enzymes are good candidates to explain inter-individual differences in response to antipsychotics. The aim of this study is to evaluate and compare the influence of the ...