Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia 

Ferreira, Pedro G.; Jares Gerboles, Pedro; Rico, Daniel; Gómez López, Gonzalo; Martínez Trillos, Alejandra; Villamor i Casas, Neus; Ecker, Simone; González-Pérez, Abel; Knowles, David G.; Monlong, Jean; Johnson, Rory; Quesada, Victor; Djebali, Sarah; Papasaikas, Panagiotis; López-Guerra, Mónica; Colomer Pujol, Dolors; Royo Moreno, Cristina; Cazorla, Maite; Pinyol, Magda; Clot Razquin, Guillem; Aymerich Gregorio, Marta; Rozman, María; Kulis, Marta; Tamborero Noguera, David; Gouin, Anaïs; Blanc, Julie; Gut, Marta; Gut, Ivo G.; Puente, Xose S.; Pisano, David G.; Martín-Subero, José Ignacio; López Bigas, Núria; López Guillermo, Armando; Valencia, Alfonso; López-Otin, Carlos; Campo Güerri, Elias; Guigó Serra, Roderic (Data de publicació: 2017-03-20)

Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying ...

Eating disorders during gestation: Implications for mother's health, fetal outcomes, and epigenetic changes 

Sebastiani, Giorgia; Andreu Fernández, Vicente; Herranz Barbero, Ana; Aldecoa, Victoria; Miracle, Xavier; Meler Barrabés, Eva; Balada Ibáñez, Arantxa; Astals Vizcaíno, Marta; Ferrero Martínez, Silvia; Gómez Roig, Ma. Dolores; García Algar, Óscar (Data de publicació: 2021-04-28)

Introduction: Eating disorders (EDs) have increased globally in women of childbearing age, related to the concern for body shape promoted in industrialized countries. Pregnancy may exacerbate a previous ED or conversely ...

Systemic and local inflammatory response in women with preterm prelabor rupture of membranes 

Cobo Cobo, María Teresa; Jacobsson, Bo; Kacerovsky, Marian; Hougaard, David M.; Skogstrand, Kristin; Gratacós Solsona, Eduard; Palacio, Montse (Data de publicació: 2018-03-20)

Objective:To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of ...

Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis 

Fernández Gómez, Javier; Clària i Enrich, Joan; Amorós, Àlex; Aguilar, Ferran; Castro, Miriam; Casulleras, Mireia; Acevedo, Juan; Duran Güell, Marta; Nuñez, Laura; Costa, Montserrat; Torres Hurtado, Mirea; Horrillo, Raquel; Ruiz-del-Árbol, Luis; Villanueva Sánchez, Càndid; Prado, Verónica; Arteaga López, Mireya; Trebicka, Jonel; Angeli, Paolo; Merli, Manuela; Alessandria, Carlo; Aagaard, Niels Kristian; Soriano Pastor, Germán; Durand, François; Gerbes, Alexander L.; Gustot, Thierry; Welzel, Tania Mara; Salerno, Francesco; Bañares, Rafael; Vargas, Víctor; Albillos, Agustín; Silva, Aníbal; Morales Ruiz, Manuel; Pavesi, Marco; Jalan, Rajiv; Bernardi, Mauro; Moreau, Richard; Páez, Antonio; Arroyo, Vicente (Data de publicació: 2020-04-27)

BACKGROUND & AIMS: We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis ...

Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice 

Mancera, Pilar; Wappenhans, Blanca; Cordobilla, Begoña; Virgili, Noemi; Pugliese, Marco; Rueda, Fèlix, 1951-; Espinosa Parrilla, Juan Francisco; Domingo, Pere (Domingo Pedrol) (Data de publicació: 2018-06-22)

Many neurodegenerative diseases are associated, at least in part, to an inflammatory process in which microglia plays a major role. The effect of the triglyceride form of the omega-3 polyunsaturated fatty acid docosahexaenoic ...

Proresolving lipid mediators and liver disease. 

Clària i Enrich, Joan; Flores Costa, Roger; Duran Güell, Marta; López Vicario, Cristina (Data de publicació: 2022-03-31)

Inflammation is a characteristic feature of virtually all acute and chronic liver diseases. It intersects different liver pathologies from the early stages of liver injury, when the inflammatory burden is mild-to-moderate, ...

Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers 

Moncunill, Gemma; Aguilar, Ruth; Ribes, Marta; Ortega, Natalia; Rubio, Rocío; Salmerón, Gemma; Molina, María José; Vidal, Marta; Barrios, Diana; Mitchell, Robert A.; Jiménez, Alfons; Castellana, Cristina; Hernández-Luis, Pablo; Rodó, Pau; Méndez, Susana; Llupià García, Anna; Puyol, Laura; Rodrigo Melero, Natalia; Carolis, Carlo; Mayor Aparicio, Alfredo Gabriel; Izquierdo, Luis; Varela, Pilar; Trilla Garcia, Antonio De Padua; Vilella, Anna; Barroso, Sonia; Angulo Aguado, Ana; Engel Rocamora, Pablo; Tortajada, Marta; Garcia-Basteiro, Alberto L.; Dobaño, Carlota, 1969- (Data de publicació: 2026-01-19)

Background: Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to ...

Exogenous Liposomal ceramide-c6 ammeliorates lipidomic profile, energy homeostasis and anti-oxidant systems in NASH 

Zanieri, Francesca; Levi, Ana; Montefusco, David; Longato, Lisa; De Chiara, Francesco; Frenguelli, Luca; Omenetti, Sara; Andreola, Fausto; Luong, Tu Vinh; Massey, Veronica; Caballeria Rovira, Joan; Fondevila Campo, Constantino; Shanmugavelandy, Sriram S.; Fox, Todd; Mazza, Giuseppe; Argemi, Josep Maria; Bataller Alberola, Ramón; Cowart, Lauren Ashley; Kester, Mark; Pinzani, Massimo; Rombouts, Krista (Data de publicació: 2021-03-10)

In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism ...

The CD200R1 Microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease 

Rabaneda Lombarte, Neus; Serratosa i Serdà, Joan; Bové, Jordi; Vila, Miquel; Saura Martí, Josep; Solà i Subirana, Carme (Data de publicació: 2022-01-28)

Background It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson's disease (PD). Consequently, the modulation of microglial activation ...

Eosinophilic Infiltration of the Sino-Atrial Node in Sudden Cardiac Death Caused by Long QT Syndrome 

Grassi, Simone; Campuzano Larrea, Oscar; Coll, Mònica; Cazzato, Francesca; Iglesias, Anna; Ausania, Francesco; Scarnicci, Francesca; Sarquella Brugada, Georgia; Brugada Terradellas, Josep, 1958-; Arena, Vicenzo; Oliva, Antonio; Brugada, Ramon (Data de publicació: 2023-06-21)

Sudden death is defined as the unexpected death of a healthy person that occurs within the first hour of the onset of symptoms or within 24 h of the victim being last seen alive. In some of these cases, rare deleterious ...

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape 

Rodríguez García, Alba; Palazón, Asis; Noguera Ortega, Estela; Powell, Daniel J.; Guedán Carrió, Sònia (Data de publicació: 2020-07-31)

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy ...

Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis 

Pulido Salgado, Marta; Vidal Taboada, José Manuel; García-Díaz Barriga, Gerardo; Serratosa i Serdà, Joan; Valente, Tony; Castillo, Paola; Matalonga, Jonathan; Straccia, Marco; Canals i Coll, Josep M.; Valledor Fernández, Annabel; Solà i Subirana, Carme; Saura Martí, Josep (Data de publicació: 2017-03-27)

Background CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for C/EBPβ show protection against excitotoxic ...

Pulmonary vascular disease in chronic lung diseases: cause or comorbidity? 

Blanco Vich, Isabel; Torres Castro , Rodrigo; Barberà i Mir, Joan Albert (Data de publicació: 2024-12-03)

To provide timely and relevant insights into the complex relationship between pulmonary vascular disease (PVD) and chronic lung disease (CLD), focusing on the causative and consequential dynamics between these conditions. ...

Role and Utility of Mixed Reality Technology in Laparoscopic Partial Nephrectomy: Outcomes of a Prospective RCT Using an Indigenously Developed Software 

Gadzhiev, Nariman; Semeniakin, Igor; Morshnev, Aleksandr; Alcaraz Asensio, Antonio; Gauhar, Vineet; Okhunov, Zhamshid (Data de publicació: 2023-08-02)

Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis 

Julià, Antonio; Gómez, Antonio; López Lasanta, María; Blanco, Francisco; Erra, Alba; Fernández Nebro, Antonio; Mas, Antonio Juan; Pérez Garcia, Carolina; García Vivar, María Luz; Sánchez Fernández, Simón; Alperi López, Mercedes; Sanmartí Sala, Raimon; Ortiz, Ana María; Fernandez Cid, Carlos M.; Díaz Torné, César; Moreno, Estefania; Li, Tianlu; Martínez Mateu, Sergio H.; Absher, Devin; Myers, Richard M.; Molina, Jesús T.; Marsal, Sara (Data de publicació: 2023-08-02)

Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation ...

Sentinel lymph node biopsy versus pelvic lymphadenectomy for early-stage cervical cancer: a retrospective institutional review 

Marina, Tiermes; Celada Castro, Cristina; Glickman, Ariel; Carreras Diéguez, Nuria; Valenzuela Rodríguez, Andrea; Fusté, Pere; Saco, Adela; Vidal i Sicart, Sergi; Torné Bladé, Aureli; Díaz Feijoo, Berta (Data de publicació: 2025-08-01)

To evaluate the oncologic and survival outcomes in patients diagnosed with early-stage cervical cancer who underwent both sentinel lymph node (SLN) and pelvic lymphadenectomy (PLD) compared with those who underwent SLN ...

Hippocampal Egr1-dependent neuronal ensembles negatively regulate motor learning 

Brito, Verónica; Montalban, Enrica; Sancho Balsells, Anna; Pupak, Anika; Flotta, Francesca; Masana Nadal, Mercè; Ginés Padrós, Silvia; Alberch i Vié, Jordi, 1959-; Martin, Claire; Girault, Jean-Antoine; Giralt Torroella, Albert (Data de publicació: 2023-02-14)

Motor skills learning is classically associated with brain regions including cerebral and cerebellar cortices and basal ganglia nuclei. Less is known about the role of the hippocampus in the acquisition and storage of motor ...

Significance of clinical-immunological patterns and diagnostic yield of biopsies in microscopic polyangiitis and granulomatosis with polyangiitis 

Fernandes Serodio, João; Prieto González, Sergio; Espígol Frigolé, Georgina; Ríos Garcés, Roberto; Gómez Caverzaschi, Verónica; Araújo Loperena, Olga; Espinosa Garriga, Gerard; Jordà Sánchez, Raül; Alba, Marco A.; Quintana, Luis; Blasco Pelicano, Miquel; Guillen, Elena; Viñas, Odette; Ruiz Ortiz, Estíbaliz; Pelegrín, Laura; Sainz de la Maza Serra, María Teresa; Sánchez Dalmau, Bernardo; García Herrera, Adriana; Solé, Manel; Castillo, Paola; Aldecoa Ansorregui, Iban; Cano, María D.; Sellarés Torres, Jacobo; Hernández González, Fernanda; Agustí, Carlos; Lucena, Carmen M.; López Rueda, Antonio; Sánchez, Marcelo; Benegas, Mariana; Capurro, Sebastián; Sanmartí Sala, Raimon; Grau Junyent, Josep M. (Josep Maria); Vilaseca, Isabel; Alobid, Isam; Cid Xutglà, M. Cinta; Hernández Rodríguez, José (Data de publicació: 2025-01-15)

Background: Microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) are the two major antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Objectives: To characterize a homogenous AAV ...

Superior effect of MP-AzeFlu than azelastine or fluticasone propionate alone on reducing inflammatory markers 

Roca i Ferrer, Jordi; Pujols Tarrés, Laura; Pérez-González, Maria; Alobid, Isam; Callejas, Francisco de Borja; Vicens Artés, Sònia; Fuentes Prado, Mireya; Valero, Antonio; Picado Vallés, César; Castor, Dennis; Nguyen, DucTung; Mullol i Miret, Joaquim (Data de publicació: 2020-06-17)

Background: MP-AzeFlu, intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), is superior to AZE or FP alone for treatment of allergic rhinitis (AR). However, the precise anti-inflammatory ...

Cord blood cardiovascular biomarkers in left-sided congenital heart disease. 

Soveral, Iris; Guirado, Laura; Escobar Diaz, María C.; Alcaide, María José; Martínez Crespo, Josep M. (Josep Maria); V Rodríguez-Sureda; Bijnens, Bart; Antolín, Eugenia; Llurba Olivé, Elisa; Bartha, José Luis; Gómez, Olga; Crispi Brillas, Fàtima (Data de publicació: 2023-02-16)

Fetal echocardiography has limited prognostic ability in the evaluation of left-sided congenital heart defects (left heart defects). Cord blood cardiovascular biomarkers could improve the prognostic evaluation of left heart ...