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Fonaments Clínics: Recent submissions

Now showing items 1-20 of 629

    Murine typhus as the leading cause of non-focalized fever in the Canary Islands 

    Vélez-Tobarias, Mónica; Torres-Vega, Ana María; Carmelo Pascual, Emma; Morais-Martín, Julio; Pérez, José Antonio; Gonzalo-Hernández. C.; Clot Razquin, Guillem; Ascaso Terrén, Carlos (Publication date: 2026-03-24)

    Purpose and methods: This prospective study aims to diagnose the etiology of non-focalized fever lasting between 5 and 28 days in the islands of La Palma and El Hierro (Canary Islands, Spain) during 2021, using serology ...

    Emotional intelligence and neurocognition profiles in first-episode psychosis: A two-year follow-up study 

    Clougher, Derek; Forte, Maria Florencia; Mezquida Mateos, Gisela; Sánchez Torres, Ana M.; Serra Navarro, Maria; Penadés Rubio, Rafael; Lobo, Antonio; González-Pinto, Ana; Panadero Gómez, Rocío; Roldán, Alexandra; Vieta i Pascual, Eduard, 1963-; Serna, Elena de la, 1978-; Trabsa, Amira; Martínez-Arán, Anabel, 1971-; Torrent Font, Carla; Tortorella, Alfonso; Menculini, Giulia; Ramos-Quiroga, Josep Antoni; Cuesta, Manuel J.; Bernardo Arroyo, Miquel; Amoretti Guadall, Silvia; PEPs Group (Publication date: 2025-10-09)

    Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles in EI and NC performance ...

    Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia 

    Gimenez, Neus; Tripathi, Rupal; Giró, Ariadna; Rosich, Laia; López Guerra, Mónica; López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; Mas, José Manuel; Pérez Galán, Patricia; Delgado, Julio (Delgado González); Campo Güerri, Elias; Farrés, Judith; Colomer Pujol, Dolors (Publication date: 2025-10-23)

    Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL ...

    Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets 

    López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; López Guerra, Mónica; Colomer Pujol, Dolors (Publication date: 2025-09-26)

    Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel alterations have been described. Some of them impact on the prognosis ...

    SF3B1 mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia 

    López Oreja, Irene; Gohr, Andre; Playa-Albinyana, Heribert; Giró, Ariadna; Arenas Ríos, Fabián; Higashi, Morihiro; Tripathi, Rupal; López Guerra, Mónica; Irimia Martínez, Manuel; Aymerich Gregorio, Marta; Valcárcel Juárez, Juan; Bonnal, Sophie; Colomer Pujol, Dolors (Publication date: 2025-11-12)

    Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations in SF3B1 are observed in 15% of patients with chronic lymphocytic leukemia ...

    Imaging Efficacy of [18F]CTT1057 PET/CT in Patients with Biochemically Recurrent Prostate Cancer: Results from GuidePath-A Phase 3, Prospective Multicenter Study 

    Fanti, Stefano; Robles Barba, Javier Jesus; Behr, Spencer; Maurer, Tobias; Paredes Barranco, Pilar; Walz, Jochen; Duch, Joan; Simo Perdigo, Marc; Mainta, Ismini Charis; Bonnefoy, Pierre Benoit; Coulanges, Medge; Tang, Jun; Seigne, Christelle; Wilke, Celine; Catafau, Ana M.; Iagaru, Andrei; Aggarwal, Rahul (Publication date: 2025-09-25)

    Improved diagnostic accuracy in patients with prostate cancer at first biochemical recurrence (BCR) with low prostate-specific antigen (PSA) levels is needed. This prospective study (GuidePath; NCT04838613) aimed to evaluate ...

    A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma 

    Mozas, Pablo; Casanueva Eliceiry, Sebastián; Rivero, Andrea; Serna, Ángel; Simó, Marc; Rodríguez, Sonia; Rivas Delgado, Alfredo; Nadeu, Ferran; Correa, Juan Gonzalo; Piñeyroa, Juan Antonio; Pérez-Valencia, Amanda Isabel; Guinetti-Ortiz, Katia; Gómez-Hernando, Marta; Giné, Eva; Delgado, Julio; Villamor i Casas, Neus; Campo, Elías; Magnano, Laura; Abrisqueta Costa, Pau; Setoain Perego, Xavier; López-Guillermo, Aramando (Publication date: 2025-01-23)

    Watchful waiting is an acceptable management strategy for advanced-stage, low tumor burden (LTB) patients with follicular lymphoma (FL). However, the prediction of how long this treatment-free observation period will last ...

    Diagnóstico prequirúrgico de gliomas difusos en adultos: perspectivas prácticas de radiólogos de Unidades de neurooncología Post-WHO 2021 

    Pons Escoda, Albert; Majós Torró, Carlos; Smits, Marion; Oleaga Zufiría, Laura (Publication date: 2024-08-30)

    La Clasificación 2021 de tumores del sistema nervioso central (SNC) por la Organización Mundial de la Salud (OMS) fue acogida con entusiasmo, aunque al principio pudo parecer abrumadora. Con el tiempo, hemos comprendido ...

    Dissemination of NDM-producing Klebsiella pneumoniae and Escherichia coli high-risk clones in Catalan healthcare institutions 

    Marí Almirall, Marta; Cosgaya Castro, Clara; Pitart, Cristina; Viñes, Joaquim; Muñoz López, Laura; Campo, Irene; Cuscó, Anna; Rodríguez Serna, Laura; Santana, Gemina; Río, Ana del; Francino, Olga; Ciruela, Pilar; Pujol, Isabel; Ballester, Frederic; Marco, Francesc; Martínez Hernández, José Alfredo; Soriano Viladomiu, Alex; Vila Estapé, Jordi; Roca Subirà, Ignasi; MERCyCAT Study Group (Publication date: 2023-12-11)

    Objectives: To characterize the clonal spread of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli isolates between different healthcare institutions in Catalonia, Spain. Methods: Antimicrobial susceptibility ...

    Halo sign in fetal cytomegalovirus infection: cerebral imaging abnormalities and postmortem histopathology in cohort of 35 infected fetuses. 

    Hawkins-Villarreal, Ameth; Castillo, Karen; Nadal Serra, Alfons; Planas i Marcé, Sílvia, 1965-; Moreno Espinosa, Ana L.; Alarcón, Ana; Rebollo Polo, Mónica; Figueras Retuerta, Francesc; Gratacós Solsona, Eduard; Eixarch Roca, Elisenda; Goncé Mellgren, Anna (Publication date: 2024-02-05)

    To evaluate the correlation of periventricular echogenic halo (halo sign) with histopathological findings and its association with other brain imaging abnormalities in fetuses with cytomegalovirus (CMV) infection.

    Genotypic and phenotypic study of antiviral resistance mutations in refractory cytomegalovirus infection 

    Santos Bravo, Marta; Nicolas Plault; Sánchez Palomino, Sonsoles; Rodríguez, Cristina; Navarro Gabriel, Mireia; Mosquera, María Mar; Fernández Avilés, Francesc; Suarez Lledó, María; Rovira, Montserrat; Bodro, Marta; Moreno Camacho, Ma. Asunción; Linares, Laura; Cofán Pujol, Federico; Berengua, Carla; Esteva, Cristina; Cordero, Elisa; Martín Dávila, Pilar; Aranzamendi, Maitane; Pérez Jiménez, Ana Belén; Vidal, Elisa; Fernández Sabé, Núria; Len, Óscar; Hantz, Sebastien; Alain, Sophie; Marcos, Ma. Angeles; the Spanish Network for Research in Infectious Diseases (REIPI); Group for the Study of Infection in Transplantation (GESITRA) (Publication date: 2023-12-04)

    Background This study describes the genotypic and phenotypic characterization of novel human cytomegalovirus (HCMV) genetic variants of a cohort of 94 clinically resistant HCMV patients. Methods and results ...

    Validation of an electronic frailty index with electronic health records: eFRAGICAP index 

    Orfila, Francesc; Carrasco Ribelles, Lucía A.; Abellana Sangrà, Rosa Mari; Roso Llorach, Albert; Cegri, Francisco; Reyes, Carlen; Violán, Concepción (Publication date: 2023-03-23)

    Objective: To create an electronic frailty index (eFRAGICAP) using electronic health records (EHR) in Catalunya (Spain) and assess its predictive validity with a two-year follow-up of the outcomes: homecare need, ...

    Performance of the Xpert MTB/RIF Ultra assay for determining cause of death by tuberculosis in tissue samples obtained by minimally invasive autopsies 

    García-Basteiro, Alberto L.; Hurtado, Juan Carlos; Castillo, Paola; Fernandes, Fabiola; Navarro, Mireia; Lovane, Lucilia; Casas, Isaac; Quintó, Llorenç; Jordao, Dercio; Smail, Mamudo Rafik; Lorenzoni, Cesaltina; Carrilho, Carla; Sanz, Ariadna; Rakislova, Natalia; Mira, Aurea; Álvarez Martínez, Míriam; Cossa, Anelsio; Cobelens, Frank; Mandomando, Inácio; Vila Estapé, Jordi; Bassat Orellana, Quique; Menéndez, Clara; Ordi i Majà, Jaume; Martínez Yoldi, Miguel Julián (Publication date: 2021-03-18)

    An estimated 1.5 million deaths were attributable to TB in 2018.1 However, some uncertainty exists as to the exact global figures, given that approximately 30% of incident cases are not diagnosed, and because of the ...

    L'Intrusisme professional a principis del segle XX. El Dr. James M. Munyon. 

    Torres, Begoña; Sabaté i Casellas, Ferran (Publication date: 2015-01-28)

    RESUM: Presentem al Dr. James M. Munyon, qui a principis del segle passat es dedicà a la manufactura i patent de remeis homeopàtics. Va ser perseguit per frau en múltiples ocasions però la seva gran fortuna li va permetre ...

    Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia 

    García Bueno, Borja; Gassó Astorga, Patricia; MacDowell, Karina S.; Callado, Luis F.; Mas Herrero, Sergi; Bernardo Arroyo, Miquel; Lafuente, Amàlia, 1952-2022; Meana, J. Javier; Leza, Juan Carlos (Publication date: 2018-01-12)

    BACKGROUND: Alterations in the innate immune/inflammatory system may underlie the pathophysiology of schizophrenia, but we do not understand the mechanisms involved. The main agents of innate immunity are the Toll-like ...

    The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing 

    Swerdlow, Steven H.; Kuzu, Isinsu; Dogan, Ahmet; Dirnhofer, Stephan; Chan, John K. C.; Sander, Birgitta; Ott, German; Xerri, Luc; Quintanilla Martinez, Leticia; Campo Güerri, Elias (Publication date: 2019-02-11)

    Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very uncommon (as in mantle cell lymphomas ...

    Review of the Microbiological Diagnostic Approaches of COVID-19 

    Melo Vallès, Ada; Ballesté Delpierre, Clara Celia; Vila Estapé, Jordi (Publication date: 2023-03-15)

    On March 12, the World Health Organization declared a pandemic following the exponential increase of SARS-CoV-2 cases. The rapid spread of the virus is due to both its high infectivity and the free circulation of unrecognized ...

    Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study 

    Coimbra, Alexandre; Rimola Gibert, Jordi; Cuatrecasas Freixas, Miriam; De Hertogh, Gert; Van Assche, Gert; Vanslembrouck, Ragna; Glerup, Henning; Hedemann Nielsen, Agnete; Hagemann-Madsen, Rikke; Bouhnik, Yoram; Zappa, Magaly; Cazals-Hatem, Dominique; D'Haens, Geert; Stoker, Jaap; Meijer, Sybren; Rogler, Gerhard; Boss, Andreas; Weber, Achim; Zhao, Rui; Keir, Mary E.; Scherl, Alexis; De Crespigny, Alex; Lu, Timothy T.; Panés Díaz, Julià (Publication date: 2023-07-31)

    Introduction: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to ...

    Association between confocal morphologic classification and clinical phenotypes of multiple primary and familial melanomas 

    Grazziotin, Thais Corsetti; Alarcon, Ivette; Bonamigo, Renan Rangel; Carrera Álvarez, Cristina; Potrony Mateu, Míriam; Aguilera, Paula; Puig Butillé, Joan Anton; Brito, Johanna; Badenas Orquin, Celia; Alós i Hernández, Llúcia; Malvehy, J. (Josep); Puig i Sardà, Susana (Publication date: 2018-02-13)

    Importance: The improved knowledge of clinical, morphologic, and epidemiologic heterogeneity of melanoma in the context of multiple primary and familial melanomas may improve prevention, diagnosis, and prognosis of melanoma. ...

    In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates 

    Portell Buj, Elena; Vergara Gómez, Andrea; Alejo-Cancho, Izaskun; López Gavín, Alexandre; Monté, Maria Rosa; San Nicolás, Lorena; González Martín, Julián; Tudó i Vilanova, Griselda (Publication date: 2019-02-15)

    Tuberculosis (TB) remains a major threat to human health worldwide. The increasing incidence of non-tuberculous mycobacterial infections and particularly those produced by ...