Bioquímica i Fisiologia: Envíos recientes
Mostrando ítems 221-240 de 634
Extracellular Vesicles of the Probiotic Escherichia coli Nissle 1917 Reduce PepT1 Levels in IL-1β Treated Caco-2 Cells via Upregulation of miR-193a-3p
PepT1, a proton-coupled oligopeptide transporter, is crucial for intestinal homeostasis. It is mainly expressed in small intestine enterocytes, facilitating the absorption of di/tri-peptides from dietary proteins. In the ...
Suppressing farnesyl diphosphate synthase alters chloroplast development and triggers sterol-dependent induction of jasmonate- and Fe-related responses
Farnesyl diphosphate synthase (FPS) catalyzes the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate. Arabidopsis (Arabidopsis thaliana) contains two genes (FPS1 and FPS2) encoding ...
BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia
Background and aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and ...
Staphylococcus epidermidis' Overload During Suckling Impacts the Immune Development in Rats
Mastitis is an inflammation of the mammary gland occurring in 3-33% of the breastfeeding mothers. The majority of mastitis cases have an infectious etiology. More than 75% of infectious mastitis are caused by Staphylococcus ...
Creation and Implementation of a New Sentinel Surveillance Model in Pharmacy Offices in Southern Europe
Traditionally, health sentinel networks have focused on the reporting of data by primary care physicians and hospitals, ignoring the role of the community pharmacist as an expert in drugs. The objective of this study was ...
Effect of a cocoa flavonoid-enriched diet on experimental autoimmune arthritis
Previously we established that a cocoa-enriched diet in young rats reduces the specific antibody production and the Th lymphocyte proportion in lymphoid tissues. The aim of the present study was to ascertain the modulatory ...
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Background & aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes to ...
Profiling and Evaluation of the Effect of Guarana-Loaded Liposomes on Different Skin Cell Lines: An In Vitro Study
Abstract The objective of this study was to analyze the in vitro stability and toxicity of liposomes containing guarana in skin cell lines. The liposomes were produced by the reverse phase evaporation method containing 1 ...
Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells
Gut microbiota plays a critical role in maintaining human intestinal homeostasis and host health. Bacterial extracellular vesicles are key players in bacteria-host communication, as they allow delivery of effector molecules ...
Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
The Ca2+-binding protein calmodulin (CaM) has been shown to bind directly to cytoplasmic domains of some G protein-coupled receptors, including the dopamine D2 receptor. CaM binds to the N-terminal portion of the long third ...
Methamphetamine Blocks Adenosine A2A Receptor Activation via Sigma 1 and Cannabinoid CB1 Receptors
Methamphetamine is, worldwide, one of the most consumed drugs of abuse. One important side effect is neurodegeneration leading to a decrease in life expectancy. The aim of this paper was to check whether the drug affects ...
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation
Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused ...
Rotavirus double infection model to study preventive dietary interventions
Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting ...
The Anti-inflammatory effect of spray-dried plasma is mediated by a reduction in mucosal lymphocyte activation and infiltration in a mouse model of intestinal inflammation.
Spray-dried preparations from porcine and bovine plasma can alleviate mucosal inflammation in experimental models and improve symptoms in patients with enteropathy. In rodents, dietary supplementation with porcine spray-dried ...
Attenuating Effect of Peruvian Cocoa Populations on the Acute Asthmatic Response in Brown Norway Rats
Cocoa contains bioactive components, which vary according to genetic and environmental factors. The present study aimed to ascertain the anti-allergic properties of native Peruvian cocoa populations ("Blanco de Piura" or ...
Identification and characterization of sterol acyltransferases responsible for steryl ester biosynthesis in tomato
Steryl esters (SEs) serve as a storage pool of sterols that helps to maintain proper levels of free sterols (FSs) in cell membranes throughout plant growth and development, and participates in the recycling of FSs and fatty ...
Association between urinary metabolic profile and the intestinal effects of cocoa in rats
The aim of this study was to elucidate the relationship between the urinary metabolic fingerprint and the effects of cocoa and cocoa fibre on body weight, hormone metabolism, intestinal immunity and microbiota composition. ...
Apremilast Microemulsion as Topical Therapy for Local Inflammation: Design, Characterization and Efficacy Evaluation
Apremilast (APR) is a selective phosphodiesterase 4 inhibitor administered orally in the treatment of moderate-to-severe plaque psoriasis and active psoriatic arthritis. The low solubility and permeability of this drug ...
Current directions in DNA gel particles
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
Estudi del mecanisme de fagocitosi dels corpora amylacea del líquid cefalorraquidi humà
Los corpora amylacea son unos cuerpos granulares que se acumulan en el cerebro humano durante el envejecimiento...
