Bioquímica i Fisiologia: Recent submissions
Now showing items 301-320 of 634
Dysruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, the involvement of mitochondrial dynamics mitigating such processes ...
NCS-1 associates with adenosine A(2A) receptors and modulates receptor function
Modulation of G protein-coupled receptor (GPCR) signaling by local changes in intracellular calcium concentration is an established function of Calmodulin (CaM) which is known to interact with many GPCRs. Less is known ...
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore ...
Activation of immune and defense responses in the intestinal mucosa by outer membrane vesicles of commensal and probiotic Escherichia coli strains
The influence of microbiota in human health is well established. Imbalances in microbiome structure have been linked to several diseases. Modulation of microbiota composition through probiotic therapy is an attempt to ...
Utilization of Glycerol for Endogenous Glucose and Glycogen Synthesis in Seabass (Dicentrarchus labrax): a Potential Mechanism for Sparing Amino Acid Catabolism in Carnivorous Fish
Glycerol is a well-tolerated additive in aquafeeds. We hypothesized that in seabass, a carnivorous fish whose endogenous carbohydrate demands are mostly met by hepatic amino acid gluconeogenesis, glycerol effectively ...
Exploring the Impact of Extra Virgin Olive Oil on Maternal Immune System and Breast Milk Composition in Rats
<span style="color:rgb( 34 , 34 , 34 )">Maternal breast milk plays a key role in providing newborns with passive immunity and stimulating the maturation of an infant’s immune system, protecting them from many diseases. It ...
5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters
5-hydroxytryptamine (5-HT) is derived from the essential amino acid L-tryptophan. Although the compound has been studied extensively for its neuronal handling and synaptic actions, serotonin 5-HT receptors can be found ...
Protective effect of guarana-loaded liposomes on hemolytic activity
Paullinia cupana var. sorbilis (Mart.) Ducke, popularly known as guarana, is one of the most promising plants in Brazilian flora and has attracted considerable interest from the scientific community owing to its numerous ...
¿Existen alternativas a los experimentos con animales?
For many centuries, humanity has been using animals for scientific knowledge and thanks to these animals much progress has been made in the development of therapies, surgery, etc. But it is known that not all trials carried ...
Attenuating Effect of Peruvian Cocoa Populations on the Acute Asthmatic Response in Brown Norway Rats
Cocoa contains bioactive components, which vary according to genetic and environmental factors. The present study aimed to ascertain the anti-allergic properties of native Peruvian cocoa populations ("Blanco de Piura" or ...
Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells
Gut microbiota plays a critical role in maintaining human intestinal homeostasis and host health. Bacterial extracellular vesicles are key players in bacteria-host communication, as they allow delivery of effector molecules ...
Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications
Ferns are poorly explored species from a pharmaceutical perspective compared to other terrestrial plants. In this work, the antioxidant and tyrosinase inhibitory activities of hydrophilic and lipophilic extracts, together ...
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation
Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused ...
Photoprotective potential of emulsions formulated with Buriti oil (Mauritia flexuosa) and Vitamin E against UV irradiation on human keratinocytes and fibroblasts cell lines
Considering the belief that natural lipids and edible substances are safer for topical applications and that carotenoids are able to protect cells against photooxidative damage, wea have investigated whether topical creams ...
Estudi del mecanisme de fagocitosi dels corpora amylacea del líquid cefalorraquidi humà
Los corpora amylacea son unos cuerpos granulares que se acumulan en el cerebro humano durante el envejecimiento...
Creation and Implementation of a New Sentinel Surveillance Model in Pharmacy Offices in Southern Europe
Traditionally, health sentinel networks have focused on the reporting of data by primary care physicians and hospitals, ignoring the role of the community pharmacist as an expert in drugs. The objective of this study was ...
Effect of a cocoa flavonoid-enriched diet on experimental autoimmune arthritis
Previously we established that a cocoa-enriched diet in young rats reduces the specific antibody production and the Th lymphocyte proportion in lymphoid tissues. The aim of the present study was to ascertain the modulatory ...
Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment
The present work is focused on the development of novel surface-functionalized poly(lactic-co-glycolic acid) nanoparticles loaded with thymol (TH-NPs) for topical administration enhancing thymol anti-inflammatory, antioxidant ...
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Background & aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes to ...
Rotavirus double infection model to study preventive dietary interventions
Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting ...
