Bioquímica i Fisiologia: Enviaments recents
Ara mostrant els elements 321-340 de 634
Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMAdifferentiated THP-1 cells
Background: In the context of tumor immunology, tumor cells have been shown to overexpress CD47, an antiphagocytic signal directed to macrophages to escape from phagocytosis by interacting with Signal Regulatory Protein α ...
Outer membrane vesicles from the probiotic Escherichia coli Nissle 1917 and the commensal ECOR12 enter intestinal epithelial cells via clathrin-dependent endocytosis and elicit differential effects on DNA damage.
Interactions between intestinal microbiota and the human host are complex. The gut mucosal surface is covered by a mucin layer that prevents bacteria from accessing the epithelial cells. Thus, the crosstalk between microbiota ...
Identification of the Ghrelin and Cannabinoid CB2 Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet
Cannabinoids have been reported as orexigenic, i.e., as promoting food intake that, among others, is controlled by the so-called "hunger" hormone, ghrelin. The aim of this paper was to look for functional and/or molecular ...
Phospholipid bilayer perturbing-properties underlying lysis induced by pH-sensitive cationic lysine-based surfactants in biomembranes
Many strategies for treating diseases require the delivery of drugs into the cell cytoplasm following internalization within endosomal vesicles. Thus, compounds triggered by low pH to disrupt membranes and release endosomal ...
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations
Large genome-wide association studies (GWAS) have increased our knowledge of the genetic risk factors of rheumatoid arthritis (RA). However, little is known about genetic susceptibility in populations with a large admixture ...
Dietary supplementation with spray-dried porcine plasma has prebiotic efects on gut microbiota in mice
In animal models of infammation and in farm animals, dietary inclusion of spray-dried porcine plasma (SDP) reduces mucosal infammation. Here, we study whether these efects could be mediated by changes in the intestinal ...
Ex Vivo and In Vivo Anti-inflammatory Evaluations of Modulated Flavanones Solutions
Abstract: Interest has developed in natural molecules due to their clinically proven effects on skin deseases. Flavanones display several biological activities, and recently have been the focus of studies due to their ...
Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis
Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female ...
ADHD subtypes are associated differently with circadian rhythms of motor activity, sleep disturbances, and body mass index in children and adolescents: a case-control study
<p>To date, few studies have examined the circadian pattern of motor activity in children and adolescents newly diagnosed with attention-deficit/hyperactivity disorder (ADHD). The objective was to study the circadian pattern ...
Absorció intestinal de monosacàrids.
El intestino es un órgano muy especializado, cuya funcion primaria es captar los nutrientes que constituyen la dieta para transferirlos al torrente sanguineo, desde donde seran distribuidos a todo el organismo. El presente ...
Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways
Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives (pharmacological GCs) constitute the first-line ...
Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats
Hesperidin, found in citrus fruits, has shown a wide range of biological properties. Nonetheless, a more in-depth investigation is required on the effects on the immune system, and in particular, on the gut-associated ...
Current directions in DNA gel particles
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus ...
Càlcul de la dosi eficaç cinquanta (DE50) mitjançant ordinador
En l'estudi de qualsevol substància medicamentosa és gairebé un pas obligat el càlcul de la dosi letal cinquanta, que hom defineix com aquella dosi que produeix la mort del 50% dels animals tractats. Per dur a terme aquesta ...
Protective effect of a cocoa-enriched diet on oxidative stress induced by intensive acute exercise in rats
Intensive acute exercise can induce oxidative stress, leading to muscle damage and immune function impairment. Cocoa diet could prevent this oxidative stress and its consequences on immunity. Our aim was to assess the ...
The Anti-inflammatory effect of spray-dried plasma is mediated by a reduction in mucosal lymphocyte activation and infiltration in a mouse model of intestinal inflammation.
Spray-dried preparations from porcine and bovine plasma can alleviate mucosal inflammation in experimental models and improve symptoms in patients with enteropathy. In rodents, dietary supplementation with porcine spray-dried ...
Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD
Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. The mechanisms that link early adiposity with late-onset chronic diseases are poorly characterised. We developed a ...
Identification and characterization of sterol acyltransferases responsible for steryl ester biosynthesis in tomato
Steryl esters (SEs) serve as a storage pool of sterols that helps to maintain proper levels of free sterols (FSs) in cell membranes throughout plant growth and development, and participates in the recycling of FSs and fatty ...
Membrane vesicles released by a hypervesiculating Escherichia coli Nissle 1917 tolR mutant are highly heterogeneous and show reduced capacity for epithelial cell interaction and entry.
Membrane vesicles (MVs) produced by Gram-negative bacteria are being explored for novel clinical applications due to their ability to deliver active molecules to distant host cells, where they can exert immunomodulatory ...
