Bioquímica i Fisiologia: Enviaments recents
Ara mostrant els elements 201-220 de 634
Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea.
Sleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic ...
JNK signaling and its impact on neural cell maturation and differentiation
C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression. However, JNKs serve key roles ...
Mevalonate biosynthesis in plants
The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR, R-mevalonate: NADP+ oxidoreductase, CoA-acylating, EC 1.1.1.34) catalyzes the reductive conversion of HMG-CoA to mevalonic acid (MVA). This reaction ...
Microbiota-Derived Extracellular Vesicles Promote Immunityand Intestinal Maturation in Suckling Rats
<p>Microbiota–host communication is primarily achieved by secreted factors that can penetrate the mucosal surface, such as extracellular membrane vesicles (EVs). The EVs released by the gut microbiota have been extensively ...
Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks ...
Reference values assessment in a Mediterranean population for small dense low-density lipoprotein concentration isolated by an optimized precipitation method
Background: High serum concentrations of small dense low-density lipoprotein cholesterol (sd-LDL-c) particles are associated with risk of cardiovascular disease (CVD). Their clinical application has been hindered as a ...
The histone demethylase PHF8 is a molecular safeguard of the IFNgamma response
A precise immune response is essential for cellular homeostasis and animal survival. The paramount importance of its control is reflected by the fact that its non-specific activation leads to inflammatory events that ...
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Fatty acid synthase (FASN) is a key lipogenic enzyme for de novo fatty acid biosynthesis and a druggable metabolic oncoprotein that is activated in most human cancers. We evaluated whether the HER2-driven lipogenic phenotype ...
Regenerable Superhydrophobic Coatings for Biomedical Fabrics
Coatings with high water repellence represent a promising field for biomedical applications. Superhydrophobicity (SH) can be used for preventing adhesion, controlling cell deposition, and spreading by inhibition of adsorption ...
Characterization and In Vivo Anti-Inflammatory Efficacy of Copal (Dacryodes peruviana (Loes.) H.J. Lam) Essential Oil
Essential oils are natural aromatic substances that contain complex mixtures of many volatile compounds frequently used in pharmaceutical and cosmetic industries. Dacryodes peruviana (Loes.) H.J. Lam is a native species ...
Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM autoantibodies
Background: Degenerative granular structures appear progressively with age in the hippocampus of most mouse strains. We recently reported that these granules contain a neo-epitope that is recognised by IgM antibodies present ...
Pharmacogenetic Variation and Its Clinical Relevance in a Latin American Rural Population
Latin-American populations have been largely underrepresented in genomic studies of drug response and disease susceptibility. In this paper, we present a genome-wide Chilean dataset from Talca based on the Illumina Global ...
Chitosan-based delivery of fish codon-optimised Caenorhabditis elegans FAT-1 and FAT-2 boosts EPA and DHA biosynthesis in Sparus aurata
Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) are essential fatty acids required in healthy balanced diets for humans. To induce sustained production of n-3 LC-PUFA in gilthead seabream (Sparus aurata), ...
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its ...
On the uptake of cationic liposomes by cells: from changes in elasticity to internalization
In this study, we assessed the capacity of a previously reported engineered liposomal formulation, which had been tested against model membranes mimicking the lipid composition of the HeLa plasma membrane, to fuse and ...
Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1.
Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate ...
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats
At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role ...
Emotional eating is associated to sleep quality in Spanish young adults
Podeu consultar el III Workshop anual INSA-UB complet a: http://hdl.handle.net/2445/118993
