Biomedicina: Recent submissions
Now showing items 41-60 of 779
IgE-related chronic diseases and anti-IgE-based treatments
IgE is an immunoglobulin that plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. The development of a drug able to neutralize this antibody represents a breakthrough in the treatment ...
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates remain unclear. We show here that cystamine increases levels of ...
Non-coding RNAs as sensors of Oxidative Stress in Neurodegeneerative Diseases
Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species and the cellular antioxidant capacity. OS plays a central role in neurodegenerative diseases, where the progressive accumulation ...
Bioengineered Bruch's-like extracellular matrix promotes retinal pigment epithelial differentiation
In the eye, the retinal pigment epithelium (RPE) adheres to a complex protein matrix known as Bruch's membrane (BrM). The aim of this study was to provide enriched conditions for RPE cell culture through the production of ...
The role of macrophage-inducible C-type lectin in different stages of chronic liver disease
The macrophage-inducible C-type lectin (mincle) is part of the innate immune system and acts as a pattern recognition receptor for pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns ...
Estado actual de la acreditación de la formación médica continuada en España
La formación médica continuada (FMC) es el conjunto de actividades educativas (estructuradas o regladas) orientadas a la adquisición, mantenimiento o mejora de la competencia profesional. De manera genérica, la FMC se suele ...
El reto educativo de El buen quehacer del médico
In March 2014 the General Council of Official Medical Associations (CGCOM) published a document entitled The Good Physician housework, which can be accessed at www.fundacioneducacionmedica.org. The document was drawn up ...
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation
The base of the primary cilium contains a zone of condensedmembranes whose importance is not known. Here, we have studiedthe involvement of MAL, a tetraspanning protein that exclusivelypartitions into condensed membrane ...
NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development
SHOX and SHOX2 transcription factors are highly homologous, with even identical homeodomains. Genetic alterations in SHOX result in two skeletal dysplasias; Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia ...
El numerus clausus de las facultades de medicina. Criterios y responsabilidades en el número de admitidos y en su distribución
Este número de la revista FEM incluye la transcripción integra de la reciente declaración del Foro de la Profesión Médica de España que, bajo el título '¿Por qué numerus clausus en medicina?', desgrana una serie de cuestiones, ...
Physical principles of membrane remodelling during cell mechanoadaptation
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope the bilayer membrane. However, the fundamental biophysical principles by which the ...
Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via reducing aortic oxidative stress
Background Increasing evidence indicates that redox stress participates in MFS aortopathy, though its mechanistic contribution is little known. We reported elevated reactive oxygen species (ROS) formation and NADPH oxidase ...
APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
BACKGROUND: The APOE effect on Alzheimer Disease (AD) risk is stronger in women than in men but its mechanisms have not been established. We assessed the APOE-by-sex interaction on core CSF biomarkers, brain metabolism and ...
Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic
The clathrin assembly lymphoid myeloid leukemia (CALM) gene encodes a putative homologue of the clathrin assembly synaptic protein AP180. Hence the biochemical properties, the subcellular localization, and the role in ...
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.
Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize ...
Recertificación de médicos: iniciativa SEPAR
Editorial del vol.18 n.3 (2015) de la publicació
La construcción de un éxito. Así se hizo nuestra sanidad pública
Ressenya del llibre 'La construcción de un éxito. Así se hizo nuestra sanidad pública'
SLAMF5 enhances autophagy and fine-tunes cytokine response in monocyte-derived dendritic cells via stabilization of Interferon regulatory Factor 8
Signaling lymphocyte activation molecule family (SLAMF) receptors are essential regulators of innate and adaptive immune responses. The function of SLAMF5/CD84, a family member with almost ubiquitous expression within the ...
High resolution ambient MS imaging of biological samples by desorption electro-flow focussing ionization
In this study, we examine the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) of biological tissue. We also compare the performance of desorption electrospray ionization ...
Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway
Diacylglycerol is necessary for trans-Golgi network (TGN) to cell surface transport, but its functional relevance in the early secretory pathway is unclear. Although depletion of diacylglycerol did not affect ER-to-Golgi ...
