Analysis of ancestral and functionally relevant CD5 variants in Systemic Lupus Erythematosus patients 

Cenit, Maria Carmen; Martínez-Florensa, Mario; Consuegra-Fernández, Marta; Bonet, Lizette; Carnero Montoro, Elena; Armiger Borràs, Noelia; Caballero Baños, Miguel; Arias, Maria Teresa; Benítez-Ribas, Daniel; Ortego Centeno, Norberto; Ramón, Enrique de; Sabio, José Mario; García Hernández, Francisco José; Tolosa Vilella, Carles; Suárez, Ana; González-Gay, Miguel A.; Bosch, Elena; Martín, Javier; Lozano Soto, Francisco (Publication date: 2017-12-14)

OBJECTIVE: CD5 plays a crucial role in autoimmunity and is a well-established genetic risk factor of developing RA. Recently, evidence of positive selection has been provided for the CD5 Pro224-Val471 haplotype in East ...

Stromal Oncostatin M cytokine promotes breast cancer progression by reprogramming the tumour microenvironment 

Araujo, Ángela M.; Abaurrea, Andrea; Azcoaga, Peio; López Velazco, Joanna I.; Manzano, Sara; Rodríguez, Javier; Rezola, Ricardo; Egia Mendikute, Leire; Valdés Mora, Fátima; Flores, Juana M.; Jenkins, Liam; Pulido, Laura; Osorio Querejeta, Iñaki; Fernandez-Nogueira, Patricia; Ferrari, Nicola; Viera, Cristina; Martin Martin, Natalia; Tzankov, Alexandar; Eppenberger Castori, Serenella; Alvarez Lopez, Isabel Manuela; Urruticoechea Ribate, Ander; Bragado Domingo, Paloma; Coleman, Nicholas; Palazón, Asis; Carracedo, Arkaitz; Gallego Ortega, David; Calvo, Fernando; Isacke, Clare M.; Caffarel, María M.; Lawrie, Charles H. (Publication date: 2024-02-09)

The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway 

Gutiérrez Martínez, Enric; Fernández Ulibarri, Inés; Lázaro Diégez, Francisco; Johannes, Ludger; Pyne, Susan; Sarri Plans, Elisabet; Egea Guri, Gustavo (Publication date: 2013-11-26)

The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER. ...

Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells 

Muñoz-Cano, Rosa; San Bartolome, Clara; Casas Saucedo, Rocio; Araujo Sánchez, Giovanna; Gelis, Sònia; Ruano Zaragoza, Maria; Roca i Ferrer, Jordi; Palomares, Francis; Martín Andorrà, Margarita; Bartra Tomàs, Joan; Pascal i Capdevila, Mariona (Publication date: 2021-06-14)

Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. ...

Divergent traits and ligand-binding properties of the cytomegalovirus CD48 gene family 

Martínez Vicente, Pablo; Farré Marimon, Domènec; Engel Rocamora, Pablo; Angulo Aguado, Ana (Publication date: 2021-02-25)

The genesis of gene families by the capture of host genes and their subsequent duplication is a crucial process in the evolution of large DNA viruses. CD48 is a cell surface molecule that interacts via its N-terminal ...

Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures 

Falgàs Martínez, Neus; Ruiz Peris, Mariona; Pérez Millan, Agnès; Sala Llonch, Roser; Antonell Boixader, Anna, 1978-; Balasa, Mircea; Borrego Écija, Sergi; Ramos Campoy, Oscar; Augé Fradera, Josep Maria; Castellví, Magdalena; Tort Merino, Adrià; Olives, Jaume; Fernández Villullas, Guadalupe; Blennow, Kaj; Zetterberg, Henrik; Bargalló Alabart, Núria; Lladó Plarrumaní, Albert; Sánchez del Valle Díaz, Raquel (Publication date: 2021-04-22)

Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid ...

Anaphylaxis: Focus on Transcription Factor Activity. 

Guo, Yanru; Proaño Pérez, Elizabeth; Muñoz-Cano, Rosa; Martín Andorrà, Margarita (Publication date: 2021-06-16)

Anaphylaxis is a severe allergic reaction, rapid in onset, and can lead to fatal consequences if not promptly treated. The incidence of anaphylaxis has risen at an alarming rate in past decades and continues to rise. ...

Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance 

Nguyen, Mai K.; Jose, Jaimy; Wahba, Mohamed; Bernaus Esqué, Marc; Hoy, Andrew J.; Enrich Bastús, Carles; Rentero Alfonso, Carles; Grewal, Thomas (Publication date: 2023-02-27)

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs, contributing to resistance to therapies. This includes a higher demand for cholesterol, which often coincides with elevated cholesterol ...

Annexins bridging the gap: novel roles in membrane contact sites formation 

Enrich Bastús, Carles; Lu, Albert; Tebar Ramon, Francesc; Rentero Alfonso, Carles; Grewal, Thomas (Publication date: 2022-02-24)

Membrane contact sites (MCS) are specialized small areas of close apposition between two different organelles that have led researchers to reconsider the dogma of intercellular communication via vesicular trafficking. The ...

Molecular Games, una herramienta de aprendizaje autónomo y gamificado de biología molecular 

Saura Martí, Josep; Santalucía Albi, Tomàs; Martí, E.; Straccia, Marco (Publication date: 2019-10-04)

Unraveling the spatiotemporal distribution of VPS13A in the mouse brain 

García-García, Esther; Chaparro Cabanillas, Nerea; Coll Manzano, Albert; Carreras Caballé, Maria; Giralt Torroella, Albert; Toro Ruiz, Daniel del; Alberch i Vié, Jordi, 1959-; Masana Nadal, Mercè; Rodríguez Allué, Manuel José (Publication date: 2021-12-14)

Loss‐of‐function mutations in the human vacuolar protein sorting the 13 homolog A (VPS13A) gene cause Chorea‐acanthocytosis (ChAc), with selective degeneration of the striatum as the main neuropathologic feature. Very ...

La Facultad de Medicina de la Universidad de Murcia espera a todos los educadores en ciencias de la salud en el XXII Congreso de la SEDEM 

Gual Sala, Arcadi (Publication date: 2017-01-24)

Since it was founded, the principal line of action of the Fundación Educación Médica (FEM) has been the incorporation and di usion of the know-how that is generated around the world in the area of medical education. To ...

Parkinsonian Neurotoxins impair the pro-inflammatory response of glial cells. 

Rabaneda Lombarte, Neus; Xicoy Espaulella, Efren; Serratosa i Serdà, Joan; Saura Martí, Josep; Solà i Subirana, Carme (Publication date: 2019-02-28)

In the case of Parkinson's disease (PD), epidemiological studies have reported that pesticide exposure is a risk factor for its pathology. It has been suggested that some chemical agents, such as rotenone and paraquat, ...

M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus 

Conde-Berriozábal, Sara; García Gilabert, Lia; García-García, Esther; Sitjà Roqueta, Laia; López Gil, Xavier; Muñoz-Moreno, Emma; Boutagouga Boudjadja, Mehdi; Soria, Guadalupe; Rodríguez Allué, Manuel José; Alberch i Vié, Jordi, 1959-; Masana Nadal, Mercè (Publication date: 2023-09-14)

Early and progressive cortico-striatal circuit alterations have been widely characterized in Huntington's disease (HD) patients. Cortical premotor area, M2 cortex in rodents, is the most affected cortical input to the ...

Standardized nanomechanical atomic force microscopy procedure (SNAP) for measuring soft and biological samples 

Schillers, Hermann; Rianna, Carmela; Schape, Jens; Luque González, Tomás; Doschke, Holger; Walte, Mike; Uriarte, Juan José; Campillo, Noelia; Michanetzis, Georgios P. A.; Bobrowska, Justyna; Dumitru, Andra; Herruzo, Elena T.; Bovio, Simone; Parot, Pierre; Galluzzi, Massimiliano; Podestà, Alessandro; Puricelli, Luca; Scheuring, Simon; Missirlis, Yannis; Garcia, Ricardo; Odorico, Michael; Teulon, Jean-Marie; Lafont, Frank; Lekka, Malgorzata; Rico Camps, Félix; Rigato, Annafrancesca; Pellequer, Jean-Luc; Oberleithner, Hans; Navajas Navarro, Daniel; Radmacher, Manfred (Publication date: 2018-11-28)

We present a procedure that allows a reliable determination of the elastic (Young's) modulus of soft samples, including living cells, by atomic force microscopy (AFM). The standardized nanomechanical AFM procedure (SNAP) ...

Estudio histológico mediante biopsia pulmonar post mortem en pacientes con neumonía por COVID-19 

Sellarés Torres, Jacobo; Guerrero, Carlos; Martínez, Daniel; Benegas, Mariana; Cuerpo Cardeñosa, Sandra; Hernández-González, Fernanda; Libreros, Alejandra; Guzmán Portillo, Rudith; Guirao Montes, Àngela; Boada, Marc; Sánchez-Lorente, David; Albacar Riobóo, Núria; Grando, Leandro; Paglialunga, Pablo; García, Francisco Javier; Faner, Rosa; Agustí García-Navarro, Àlvar; Sibila Vidal, Oriol; Sanchez, Marcelo; Molins López-Rodó, Laureano; Ramírez Ruz, J. (José) (Publication date: 2023-03-07)

Los estudios de anatomía patológica (AP) del pulmón en pacientes que fallecen por COVID-19 nos han permitido entender el daño pulmonar producido por el virus SARS-CoV-21,2. En el contexto de la pandemia COVID-19, la ...

AMEE Conference: de Glasgow 2015 a Barcelona 2016 [Editorial] 

Palés, J. L. (Jorge Luis) (Publication date: 2016-11-14)

La Association for Medical Education in Europe (AMEE), fundada en 1972 por iniciativa de diferentes sociedades nacionales de educación médica- entre ellas la Sociedad Española de Educación Médica (SEDEM)-, viene celebrando ...

Biomarkers predicting antidepressant treatment response - how can we advance the field? 

Labermaier, Christiana; Masana Nadal, Mercè; Müller, Marianne B. (Publication date: 2024-01-29)

Major depression, affecting an estimated 350 million people worldwide, poses a serious social and economic threat to modern societies. There are currently two major problems calling for innovative research approaches, ...

Resveratrol attenuates intermittent hypoxia-induced macrophage migration to visceral white adipose tissue and insulin resistance in male mice. 

Carreras, Alba; Zhang, Shelley X.L.; Almendros López, Isaac; Wang, Yang; Peris, Eduard; Qiao, Zhuanhong; Gozal, David (Publication date: 2016-09-21)

Chronic intermittent hypoxia during sleep (IH), as occurs in sleep apnea, promotes systemic insulin resistance. Resveratrol (Resv) has been reported to ameliorate high-fat diet-induced obesity, inflammation, and insulin ...

ERS International Congress, Madrid, 2019: highlights from the Sleep and Clinical Physiology Assembly 

Crespo, Andrea; Baillieul, Sebastien; Marhuenda, Esther; Bradicich, Matteo; Andrianopoulos, Vasileios; Zafeiris, Louvaris; Marillier, Mathieu; Almendros López, Isaac (Publication date: 2023-03-23)

The 2019 European Respiratory Society (ERS) International Congress took place in Madrid, Spain, and served as a platform to find out the latest advances in respiratory diseases research. The research aims are to understand ...