Biomedicina: Recent submissions
Now showing items 41-60 of 779
Distinct functional activity of the precuneus and posterior cingulate cortex during encoding in the preclinical stage of Alzheimer's Disease
In this study functional magnetic resonance imaging (fMRI) is used to investigate the functional brain activation pattern in the preclinical stage of AD (pre-AD) subjects during a visual encoding memory task. Thirty subjects, ...
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
The human gut includes plasma cells (PCs) expressing immunoglobulin A1 (IgA1) or IgA2, two structurally distinct IgA subclasses with elusive regulation, function, and reactivity. We show here that intestinal IgA1+ and IgA2+ ...
The possible future roles for IPSC-Derived therapy for Autoimmune Diseases.
The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential ...
α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions
During spreading and migration, the leading edges of cells undergo periodic protrusion-retraction cycles. The functional purpose of these cycles is unclear. Here, using submicrometer polydimethylsiloxane pillars as substrates ...
First Organoid Intelligence (OI) workshop to form an OI community
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while ...
Inhibiting H3K27 Demethylases Downregulates CREB-CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia
Background: CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel ...
Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices
The mechanical properties of the extracellular matrix (ECM)–a complex, 3D, fibrillar scaffold of cells in physiological environments–modulate cell behavior and can drive tissue morphogenesis, regeneration, and disease ...
Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK.
Professor Peter Rothwell of Oxford University chaired the annual Scientific Conference of the International Aspirin Foundation in London on 28 August 2015. It took the form of four sessions. Aspirin has more than one action ...
¿Qué opinan los expertos en educación médica sobre la sentencia de la troncalidad? What do the experts in medical education think about the ruling on the core curriculum?
Desde la Sociedad Española de Educación Médica (SEDEM) y desde la Fundación Educación Médica (FEM) ya hemos manifestado en diversos ámbitos, que la tronca lidad transformaría el SNS.
TRPV2: A Key Player in Myelination Disorders of the Central Nervous System
Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, ...
Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung
Senescence in cancer cells acts as a tumor suppressor, whereas in fibroblasts enhances tumor growth. Senescence has been reported in tumor associated fibroblasts (TAFs) from a growing list of cancer subtypes. However, the ...
Pharmacogenetic Modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and ...
Functional Interaction Between Caveolin 1 and LRRC8-Mediated Volume-Regulated Anion Channel
Volume-regulated anion channel (VRAC), constituted by leucine-rich repeat-containing 8 (LRRC8) heteromers, is crucial for volume homeostasis in vertebrate cells. This widely expressed channel has been associated with ...
Microarray-based analysis of plasma cirDNA epigenetic modification profiling in xenografted mice exposed to intermittent hypoxia
Intermittent hypoxia (IH) during sleep is one of the major abnormalities occurring in patients suffering from obstructive sleep apnea (OSA), a highly prevalent disorder affecting 6-15% of the general population, particularly ...
Mediterranean dietary pattern is associated to low risk of aggressive prostate cancer: MCC-Spain study.
Purpose: We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. Materials and Methods: MCC-Spain ...
Extracellular vesicles secreted by triple-negative breast cancer stem cells trigger premetastatic niche remodeling and metastatic growth in the lungs
Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the premetastatic niche (PMN) to support cancer cell engraftment and metastatic growth. ...
Novel Decellularization Method for Tissue Slices
Decellularization procedures have been developed and optimized for the entire organ or tissue blocks, by either perfusion of decellularizing agents through the tissue’s vasculature or submerging large sections in decellularizing ...
Clinical significance and applications of oscillometry
Recently, 'Technical standards for respiratory oscillometry' was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, ...
Cognitive dysfunction in Huntington¿s disease: Humans, mouse models and molecular mechanisms
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder due to an expanded CAG/polyglutamine repeat in the coding region of the huntingtin (htt) gene that causes the preferential degeneration ...
Genetic and Epigenetic Associations with Pre-Chronic Obstructive Pulmonary Disease Lung Function Trajectories
Understanding the molecular mechanisms of lung function trajectories that progress to chronic obstructive pulmonary disease (COPD) (pre-COPD trajectories), especially those with a rapidly declining phenotype, should inform ...
