Biomedicina: Recent submissions
Now showing items 1-20 of 779
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
Unjamming transitions from a solid-like to a fluid-like state are a gateway to breast epithelial cancer invasion. However, the mechanical interplay between phase transitions and dimension transitions, in particular wetting, ...
Optimal collective durotaxis through E-cadherin adhesions
The directed migration of cellular clusters enables morphogenesis, wound healing, and collective cancer invasion. Gradients of substrate stiffness are known to direct the migration of cellular clusters in a process called ...
Pre-COPD: an evolving concept with practice potential
COPD is the third leading cause of death globally and remains a major public health burden. Despite its substantial impact, effective prevention remains challenging. COPD is currently defined as having FEV<sub>1</sub>/FVC ...
General population-based lung function trajectories over the life course: an accelerated cohort study
Background Lung function is a key determinant of health, but current knowledge on lung function growth and decline over the life course is based on fragmented, potentially biased data. We aimed to empirically derive general ...
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming
Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in a controlled spatiotemporal manner in two ...
Human microglia-like cells differentiated from monocytes with GM-CSF and IL-34 show phagocytosis of α-synuclein aggregates and C/EBPβ-dependent proinflammatory activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial ...
Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI
Background: Brain areas interact mutually to perform particular complex brain functions such as memory or language. Furthermore, under resting-state conditions several spatial patterns have been identified that resemble ...
Nuclear stiffness through lamin A/C overexpression differentially modulates chromosomal instability biomarkers
Background Information Mitosis is crucial for the faithful transmission of genetic material, and disruptions can result in chromosomal instability (CIN), a hallmark of cancer. CIN is a known driver of tumor heterogeneity ...
Competing signaling pathways controls electrotaxis
Understanding how cells follow exogenous cues is a key question for biology, medicine, and bioengineering. Growing evidence shows that electric fields represent a precise and programmable method to control cell migration. ...
Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects
Alzheimer’s disease is characterized by progressive cognitive decline, and its effects are mitigated by cognitivereserve. We investigated whether long-term cognitive stimulation, initiated before amyloid deposition,preserves ...
Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR). A prospective cohort study of singleton pregnancies including ...
Low-cost, open-source device for applying controlled olfactory stimuli during functional magnetic resonance imaging (fMRI) of the brain
Using functional magnetic resonance imaging (fMRI) to assess brain activity in response to olfactory stimuli is of great biomedical and clinical interest. However, application of controlled sequences of olfactory stimuli ...
Structural brain changes in post-COVID condition and its relationship with cognitive impairment
It has been estimated that ∼4% of individuals infected with SARS-CoV-2 will be diagnosed with post-COVID condition. Previous studies have evidenced the presence of cognitive dysfunction and structural brain changes in ...
MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors
The role of Microphthalmia-associated Transcription Factor (MITF) in gastrointestinal stromal tumors (GISTs) remains unclear, although previous studies suggest it contributes to tumor growth regulation. Previously, we ...
Photoactivated adenylyl cyclase in cortical astrocytes promotes synaptic potentiation and reveals alterations in Huntington’s Disease
Coordinated neuron-astrocyte interactions are crucial for synaptic plasticity and brain function. Cyclic adenosine monophosphate (cAMP) pathways have a key role in modulating plasticity and are disrupted in neurodegenerative ...
Obese Asthma Syndrome: Multiple Inflammatory Patterns and A Key Solution
Obesity frequently complicates the pathobiology, diagnosis, and management of asthma. Traditionally, obese asthma patients have been classified as presenting either early-onset obese asthma, characterized by atopy and type ...
Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning
Dravet syndrome (DS) is a developmental epileptic encephalopathy (DEE) driven by pathogenic variants in the SCN1A gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, ...
Andronet News. Winter 2022/2023
After the Holiday Season at the end of 2022, followed by January ‘hibernation’, we are beginning to work towards the objectives of our Action
Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice
RNA helicase DHX15 plays a significant role in vasculature development and lung metastasis in vertebrates. In addition, several studies have demonstrated the overexpression of DHX15 in the context of hepatocellular carcinoma. ...
MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway.
MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate ...
